INT204340

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 25.18
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADIPOQ) extracellular space (ADIPOQ) extracellular region (ADIPOQ)
endoplasmic reticulum (ADIPOQ)
Anatomy Link Frequency
adipocytes 5
endocrine organ 2
myocardium 1
coronary artery 1
immune cells 1
ADIPOQ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 256 100.00 Very High Very High Very High
cytokine 50 100.00 Very High Very High Very High
Inflammatory response 11 96.52 Very High Very High Very High
Inflammatory marker 11 96.04 Very High Very High Very High
headache 2 86.52 High High
withdrawal 1 86.16 High High
depression 71 84.48 Quite High
antidepressant 83 84.16 Quite High
Angina 16 83.24 Quite High
tolerance 53 80.44 Quite High
Disease Link Frequency Relevance Heat
Obesity 585 100.00 Very High Very High Very High
INFLAMMATION 294 100.00 Very High Very High Very High
Cancer 38 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Syndrome 36 99.92 Very High Very High Very High
Myocardial Infarction 46 98.72 Very High Very High Very High
Insulin Resistance 226 98.68 Very High Very High Very High
Atherosclerosis 58 97.96 Very High Very High Very High
Increased Venous Pressure Under Development 68 97.92 Very High Very High Very High
Thrombosis 7 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exact mechanism of adiponectin decrease immediately after the onset of AMI remains unknown.
Localization (decrease) of adiponectin associated with myocardial infarction
1) Confidence 0.75 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2694800 Disease Relevance 1.80 Pain Relevance 0.19
Synthesis and secretion of adiponectin by adipocytes, or interaction with specific
    adiponectin receptors might be impaired in obese individuals. 
Localization (secretion) of adiponectin in adipocytes associated with obesity
2) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.63 Pain Relevance 0.03
According to McTernan et al. [17], adipose tissue plays a prominent role in the clinical expression of metabolic syndrome, most likely mediated by the increased release and peripheral tissue action of non-esterified fatty acids and by the dysregulated production of adipocyte-secreted proteins, including leptin, adiponectin, resistin, TNF-?
Localization (secreted) of adiponectin in adipocyte associated with obesity and metabolic syndrome
3) Confidence 0.54 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 1.21 Pain Relevance 0
Adipose tissue is now regarded as an endocrine organ and secretes several adipokines, such as adiponectin, resistin, plasminogen activating inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) [29]–[31].
Localization (secretes) of adiponectin in endocrine organ associated with obesity
4) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.34 Pain Relevance 0.36
Adiponectin that is secreted exclusively by adipocytes has recently been recognized as an important marker of cardiometabolic syndrome, obesity, type 2 diabetes, and coronary artery disease.
Localization (secreted) of Adiponectin in coronary artery associated with coronary artery disease, diabetes mellitus, syndrome and obesity
5) Confidence 0.51 Published 2007 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC1994046 Disease Relevance 2.03 Pain Relevance 0.04
Adipocytes are metabolically active cells which secrete tumor necrosis factor alpha, interleukin 6, plasminogen activator inhibitor-1, leptin, resistin, adiponectin, and angiotensinogen (Rondinone 2006; Yu and Ginsberg 2005).
Localization (secrete) of adiponectin in Adipocytes associated with necrosis, cancer and obesity
6) Confidence 0.51 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.62 Pain Relevance 0
Adiponectin is secreted exclusively by adipocytes and levels are reduced in obesity, type 2 diabetes and coronary heart disease.
Localization (secreted) of Adiponectin in heart associated with diabetes mellitus, obesity and coronary heart disease
7) Confidence 0.51 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.99 Pain Relevance 0.10
Mechanistically, it has been suggested that adiponectin concentrations increase with age due in part to an age-related decline in renal clearance of adiponectin (41).
Localization (clearance) of adiponectin
8) Confidence 0.51 Published 2010 Journal Diabetes Section Body Doc Link PMC2797949 Disease Relevance 0.62 Pain Relevance 0.15
For these analyses, natural log-transformations were performed to approximate normality of CRP, IL-6, adiponectin, resistin, PAI-1 and RBP4, as they were not normally distributed.
Localization (normality) of adiponectin
9) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.19 Pain Relevance 0.20
We hypothesize that some of the metabolic benefits induced by caloric restriction may result from improved secretion of adipokines such as adiponectin.
Localization (secretion) of adiponectin
10) Confidence 0.47 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
Adiponectin, a hormone derived from the adipose tissue, is considered an insulin sensitizer and it upholds both anti-atherogenic and anti-inflammatory effects [2,7,8].
Localization (sensitizer) of Adiponectin in adipose tissue associated with inflammation and obesity
11) Confidence 0.45 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC3009968 Disease Relevance 1.35 Pain Relevance 0.19
, interleukin-6 (IL-6), and adiponectin secreted from adipocytes and immune cells are predictors of vascular disease and insulin resistance [26].
Localization (secreted) of adiponectin in immune cells associated with obesity, insulin resistance and increased venous pressure under development
12) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2872762 Disease Relevance 1.52 Pain Relevance 0.45
Adipocytes express and secrete a variety of adipokines including cytokines, growth factors, adiponectin, resistin, adipsin, leptin, acylation stimulating protein, plasminogen activator inhibitor-1 (PAI-1), lipoprotein lipase, and components of the renin-angiotensin system which may exert local (autocrine/paracrine) and systemic (endocrine) effects [67–69].

5.2.

Localization (secrete) of adiponectin in Adipocytes associated with obesity and cytokine
13) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.47 Pain Relevance 0.13
We also performed a study of the time-course effects of lactoferrin, together with appropriate controls for cell integrity (LDH release) (Fig. 6) and specificity (adiponectin).
Localization (release) of adiponectin
14) Confidence 0.22 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.26 Pain Relevance 0
Conversely, the expression and secretion of adiponectin, an adipocyte-specific protein that enhances insulin-mediated glucose uptake, is inversely correlated with fat mass (Lyon et al 2003).
Localization (secretion) of adiponectin in fat
15) Confidence 0.20 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.71 Pain Relevance 0
Adipose tissue is a known endocrine organ secreting several soluble factors, known as adipocytokines or adipokines, some of these being adiponectin, leptin, resistin and, more recently, visfatin.
Localization (secreting) of adiponectin in endocrine organ associated with obesity
16) Confidence 0.17 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2857825 Disease Relevance 1.99 Pain Relevance 0.03
All other metabolites were analyzed according to the manufacturer's guidelines using ELISA-based assays for leptin (R&D Systems, DLP00, Minneapolis, MN), C-reactive protein (CRP) (Alpha Diagnostic, U54401841, San Antonio, TX), adiponectin (R&D Systems, DY1065, Minneapolis, MN), and interleukin-6 (I-L6) (R&D Systems, HS600B, Minneapolis, MN).
Localization (assays) of adiponectin
17) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.23 Pain Relevance 0
, interleukin-6 (IL-6), and adiponectin secreted from adipocytes and immune cells are predictors of vascular disease and insulin resistance [26].
Localization (secreted) of adiponectin in adipocytes associated with obesity, insulin resistance and increased venous pressure under development
18) Confidence 0.13 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2872762 Disease Relevance 1.52 Pain Relevance 0.45
It is an important modulator of endothelial function via secretion of a variety of hormones, including adiponectin, resistin, leptin, PAI-1, angiotensin, estradiol, and the cytokines TNF?
Localization (secretion) of adiponectin associated with cytokine
19) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.71 Pain Relevance 0.10
It was recently suggested to have health benefits by modulating the state of coronary arteries and myocardium through paracrine and direct secretion of pro and anti-inflammatory adipokines, including increased adiponectin production ([154] and references therein).
Localization (secretion) of adiponectin in myocardium associated with inflammation
20) Confidence 0.09 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.76 Pain Relevance 0.23

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