INT204342

Context Info Confidence 0.46 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.89 Pain Relevance 0.42

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)

Anatomy Link Frequency motor nerve 2 TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate receptor 5 97.76 Glutamate 40 97.04 Neurotransmitter 2 96.84 Neuronal excitability 25 96.56 Action potential 12 5.00 hyperexcitability 9 5.00 potassium channel 3 5.00 sodium channel 2 5.00 tetrodotoxin 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Epilepsy 8 86.28 Neurological Disease 6 85.56 Autism 3 76.16 Neurofibromatosis 2 75.28 Schizophrenia 4 61.56 Anxiety Disorder 3 51.84 Stress 10 24.16 Body Weight 1 11.76 Obesity 12 5.00 Aging 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.

Positive_regulation (increase) of Negative_regulation (levels) of TFAM

1) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0

In this mechanism, activation by the excitatory neurotransmitter glutamate of metabotropic glutamate receptors (mGluRs) located at motor nerve terminals decreases excitability by activating PI3 kinase (PI3K), consequently causing the phosphorylation and inhibition of the transcription factor Foxo.

Positive_regulation (causing) of Negative_regulation (inhibition) of transcription factor in motor nerve associated with glutamate, neurotransmitter and glutamate receptor

2) Confidence 0.00 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2581892 Disease Relevance 0.89 Pain Relevance 0.42

General Comments

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