INT204342

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
Anatomy Link Frequency
motor nerve 2
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 5 97.76 Very High Very High Very High
Glutamate 40 97.04 Very High Very High Very High
Neurotransmitter 2 96.84 Very High Very High Very High
Neuronal excitability 25 96.56 Very High Very High Very High
Action potential 12 5.00 Very Low Very Low Very Low
hyperexcitability 9 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 8 86.28 High High
Neurological Disease 6 85.56 High High
Autism 3 76.16 Quite High
Neurofibromatosis 2 75.28 Quite High
Schizophrenia 4 61.56 Quite High
Anxiety Disorder 3 51.84 Quite High
Stress 10 24.16 Low Low
Body Weight 1 11.76 Low Low
Obesity 12 5.00 Very Low Very Low Very Low
Aging 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Positive_regulation (increase) of Negative_regulation (levels) of TFAM
1) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
In this mechanism, activation by the excitatory neurotransmitter glutamate of metabotropic glutamate receptors (mGluRs) located at motor nerve terminals decreases excitability by activating PI3 kinase (PI3K), consequently causing the phosphorylation and inhibition of the transcription factor Foxo.
Positive_regulation (causing) of Negative_regulation (inhibition) of transcription factor in motor nerve associated with glutamate, neurotransmitter and glutamate receptor
2) Confidence 0.00 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2581892 Disease Relevance 0.89 Pain Relevance 0.42

General Comments

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