INT204343

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 3 27.48 Quite Low
Dismenorea 3 18.48 Low Low
Spinal cord 24 5.00 Very Low Very Low Very Low
Action potential 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Sciatic nerve 6 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 70 99.54 Very High Very High Very High
Carcinoma 60 99.08 Very High Very High Very High
Cancer 96 98.52 Very High Very High Very High
Stress 50 98.00 Very High Very High Very High
Endometroid Carcinoma 108 97.56 Very High Very High Very High
Aging 44 96.64 Very High Very High Very High
Metastasis 27 94.04 High High
Diabetes Mellitus 28 77.40 Quite High
Clear Cell Adenocarcinoma 9 76.48 Quite High
Endometrial Cancer 27 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Correlation analysis between mtTFA and p53 expression by using the Pearson test showed significant correlation in endometrioid adenocarcinomas (P?
Positive_regulation (between) of Gene_expression (expression) of mtTFA associated with endometroid carcinoma
1) Confidence 0.50 Published 2010 Journal Virchows Arch Section Abstract Doc Link PMC2852529 Disease Relevance 1.26 Pain Relevance 0
Correlation analysis between mtTFA and p53 expression by using the Pearson test showed significant correlation in endometrioid adenocarcinomas (P?
Positive_regulation (between) of Gene_expression (expression) of mtTFA associated with endometroid carcinoma
2) Confidence 0.50 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.42 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM and PPARGC1A and induced mitochondrial biogenesis.
Positive_regulation (increase) of Gene_expression (expression) of TFAM
3) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.31 Pain Relevance 0
M of DETA-NO increased the mRNA expression of TFAM (0.62 ± 0.1 versus 1.3 ± 0.1, p < 0.001) and induced mitochondrial biogenesis (indicated by MitotrackerGreen, Figure 3A).
Neg (NO) Positive_regulation (increased) of Gene_expression (expression) of TFAM
4) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
The Mann–Whitney U test was used for comparison of clinicopathological variables with positive and negative mtTFA expression.
Positive_regulation (negative) of Gene_expression (expression) of mtTFA
5) Confidence 0.43 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 0.25 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Positive_regulation (caused) of Gene_expression (expression) of transcription factor
6) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Positive_regulation (increase) of Gene_expression (expression) of transcription factor
7) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
The activation of ERK1/2 and Akt in de-ATSC via hypoxia/DHP-d resulted in the induction of stemness transcription factor expression, and in particular, Rex1 expression (Figure 3A).
Positive_regulation (induction) of Gene_expression (expression) of transcription factor associated with hypoxia
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.42 Pain Relevance 0
Our results show that ATSC can undergo an increase in developmental potential following reprogramming via the overexpression of the embryonic transcription factor, Rex1, Oct4, and Oct4-dependent Nanog and Sox2.
Positive_regulation (overexpression) of Gene_expression (overexpression) of transcription factor
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.21 Pain Relevance 0

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