INT204343

Context Info Confidence 0.50 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 7 Total Number 9 Disease Relevance 3.87 Pain Relevance 0

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)

TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 3 27.48 Dismenorea 3 18.48 Spinal cord 24 5.00 Action potential 8 5.00 anesthesia 6 5.00 Potency 6 5.00 Sciatic nerve 6 5.00 withdrawal 2 5.00

Disease Link Frequency Relevance Heat Hypoxia 70 99.54 Carcinoma 60 99.08 Cancer 96 98.52 Stress 50 98.00 Endometroid Carcinoma 108 97.56 Aging 44 96.64 Metastasis 27 94.04 Diabetes Mellitus 28 77.40 Clear Cell Adenocarcinoma 9 76.48 Endometrial Cancer 27 75.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Correlation analysis between mtTFA and p53 expression by using the Pearson test showed significant correlation in endometrioid adenocarcinomas (P?

Positive_regulation (between) of Gene_expression (expression) of mtTFA associated with endometroid carcinoma

1) Confidence 0.50 Published 2010 Journal Virchows Arch Section Abstract Doc Link PMC2852529 Disease Relevance 1.26 Pain Relevance 0

Correlation analysis between mtTFA and p53 expression by using the Pearson test showed significant correlation in endometrioid adenocarcinomas (P?

Positive_regulation (between) of Gene_expression (expression) of mtTFA associated with endometroid carcinoma

2) Confidence 0.50 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.42 Pain Relevance 0

Six months of caloric restriction caused an increase in the expression levels of TFAM and PPARGC1A and induced mitochondrial biogenesis.

Positive_regulation (increase) of Gene_expression (expression) of TFAM

3) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.31 Pain Relevance 0

M of DETA-NO increased the mRNA expression of TFAM (0.62 ± 0.1 versus 1.3 ± 0.1, p < 0.001) and induced mitochondrial biogenesis (indicated by MitotrackerGreen, Figure 3A).

Neg (NO) Positive_regulation (increased) of Gene_expression (expression) of TFAM

4) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0

The Mann–Whitney U test was used for comparison of clinicopathological variables with positive and negative mtTFA expression.

Positive_regulation (negative) of Gene_expression (expression) of mtTFA

5) Confidence 0.43 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 0.25 Pain Relevance 0

Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.

Positive_regulation (caused) of Gene_expression (expression) of transcription factor

6) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0

Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.

Positive_regulation (increase) of Gene_expression (expression) of transcription factor

7) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0

The activation of ERK1/2 and Akt in de-ATSC via hypoxia/DHP-d resulted in the induction of stemness transcription factor expression, and in particular, Rex1 expression (Figure 3A).

Positive_regulation (induction) of Gene_expression (expression) of transcription factor associated with hypoxia

8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.42 Pain Relevance 0

Our results show that ATSC can undergo an increase in developmental potential following reprogramming via the overexpression of the embryonic transcription factor, Rex1, Oct4, and Oct4-dependent Nanog and Sox2.

Positive_regulation (overexpression) of Gene_expression (overexpression) of transcription factor

9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.21 Pain Relevance 0

General Comments

This test has worked.