INT204345

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometroid Carcinoma 36 99.16 Very High Very High Very High
Cancer 32 98.16 Very High Very High Very High
Apoptosis 6 91.88 High High
Skin Cancer 2 88.44 High High
Targeted Disruption 3 79.24 Quite High
Carcinoma 20 72.64 Quite High
Endometrial Cancer 9 50.00 Quite Low
Stress 22 27.04 Quite Low
Malignant Neoplastic Disease 2 22.48 Low Low
Body Weight 2 11.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the positive mtTFA expression is a useful maker for the progression of the tumors and the poor prognosis of the patients in endometrioid adenocarcinomas.
Negative_regulation (positive) of Gene_expression (expression) of mtTFA associated with endometroid carcinoma and cancer
1) Confidence 0.42 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.48 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Negative_regulation (levels) of Gene_expression (expression) of TFAM
2) Confidence 0.39 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Negative_regulation (levels) of Gene_expression (expression) of transcription factor
3) Confidence 0.34 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0

General Comments

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