INT204347

Context Info Confidence 0.49 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytosol (PPARGC1A) mRNA processing (PPARGC1A) RNA binding (PPARGC1A) mitochondrion organization (PPARGC1A) nucleus (PPARGC1A) protein complex assembly (PPARGC1A)

PPARGC1A (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Stress 10 31.60 Body Weight 1 11.76 Obesity 11 5.00 Aging 8 5.00 Overweight 6 5.00 Weight Loss 2 5.00 Chronic Disease 2 5.00 Heart Disease 1 5.00 Helminth Infection 1 5.00 Diabetes Mellitus 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.

Positive_regulation (increase) of Negative_regulation (levels) of PPARGC1A

1) Confidence 0.49 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0

General Comments

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