INT204349

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1)
nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)
Anatomy Link Frequency
muscle 1
skeletal muscle 1
myotubes 1
SIRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 43.88 Quite Low
Hippocampus 26 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 124 99.28 Very High Very High Very High
Stress 76 99.18 Very High Very High Very High
Obesity 77 98.34 Very High Very High Very High
Cognitive Disorder 316 95.04 Very High Very High Very High
Overweight 44 76.00 Quite High
Endometriosis (extended) 2 73.04 Quite High
Appetite Loss 7 59.24 Quite High
Targeted Disruption 7 38.92 Quite Low
Diabetes Mellitus 13 32.28 Quite Low
Lifespan 12 31.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that additional factors may be involved in improving mitochondrial function and regulating SIRT1 activity in response to caloric restriction in human muscle.
Regulation (regulating) of SIRT1 in muscle
1) Confidence 0.61 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05).
Regulation (involved) of SIRT1
2) Confidence 0.44 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0
In this study, NO treatment did not change SIRT1 protein content in primary human myotubes.
Neg (not) Regulation (change) of SIRT1 protein in myotubes
3) Confidence 0.44 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.09 Pain Relevance 0
In murine white adipocytes NO treatment increases SIRT1 protein [7], suggesting eNOS may also be involved in regulating SIRT1 in skeletal muscle.
Regulation (regulating) of SIRT1 in skeletal muscle associated with obesity
4) Confidence 0.44 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.10 Pain Relevance 0
These cells showed greater resistance to stress (increased heat resistance) and also up-regulation of the sirtuin 1 (SIRT1) gene, linked to longevity.
Regulation (regulation) of sirtuin 1 associated with stress and aging
5) Confidence 0.43 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2999838 Disease Relevance 0.61 Pain Relevance 0
These cells showed greater resistance to stress (increased heat resistance) and also up-regulation of the sirtuin 1 (SIRT1) gene, linked to longevity.
Regulation (regulation) of SIRT1 associated with stress and aging
6) Confidence 0.43 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2999838 Disease Relevance 0.61 Pain Relevance 0
The change in eNOS mRNA from baseline was highly correlated with the change in the expression of PPARGC1A and SIRT1 in the CR group (r = 0.86, p < 0.001 and r = 0.80, p < 0.001, respectively; unpublished data), suggesting synergistic regulation among PPARGC1A, SIRT1, and eNOS.
Regulation (regulation) of SIRT1
7) Confidence 0.27 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.06 Pain Relevance 0
g/ml globular adiponectin increased SIRT1 protein (Figure 3D, bottom) but had no effect on SIRT1 mRNA (unpublished data), indicating post-transcriptional regulation.
Neg (no) Regulation (effect) of SIRT1
8) Confidence 0.27 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.14 Pain Relevance 0
A possible discrepancy between the study by Nisoli et al. [7] and ours may relate to tissue- or pathway-specific regulation of SIRT1 [7,11].
Regulation (regulation) of SIRT1
9) Confidence 0.23 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.09 Pain Relevance 0

General Comments

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