INT204350

Context Info Confidence 0.41 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 0

cytosol (PPARGC1A) mRNA processing (PPARGC1A) RNA binding (PPARGC1A) mitochondrion organization (PPARGC1A) nucleus (PPARGC1A) protein complex assembly (PPARGC1A)

PPARGC1A (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 1 99.64 Apoptosis 1 36.04 Obesity 11 6.76 Weight Loss 2 6.40 Stress 10 5.00 Aging 8 5.00 Overweight 6 5.00 Chronic Disease 2 5.00 Heart Disease 1 5.00 Helminth Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In rodents, knockout of the eNOS gene abolishes the caloric restriction-induced expression of PPARGC1A and TFAM mRNA and mitochondrial protein content [7].

Negative_regulation (abolishes) of Transcription (expression) of PPARGC1A associated with targeted disruption

1) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.10 Pain Relevance 0

General Comments

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