INT204353

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1)
nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)
SIRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 33 100.00 Very High Very High Very High
Stress 30 93.84 High High
Shock 1 74.20 Quite High
Targeted Disruption 2 74.16 Quite High
Obesity 22 22.20 Low Low
Weight Loss 4 21.84 Low Low
Aging 18 5.00 Very Low Very Low Very Low
Overweight 12 5.00 Very Low Very Low Very Low
Chronic Disease 4 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Baseline mRNA expression of PPARGC1A and SIRT1 were highly correlated in all groups (control, r = 0.81, p < 0.001; CR, r = 0.86, p < 0.001; and CREX, r = 0.85, p < 0.001).
Transcription (expression) of SIRT1
1) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.09 Pain Relevance 0
This might be expected to change SIRT1 activity and gene transcription.
Transcription (transcription) of SIRT1
2) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.13 Pain Relevance 0
The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners

Background

Transcription (expression) of sirtuin associated with apoptosis
3) Confidence 0.52 Published 2010 Journal BMC Physiol Section Title Doc Link PMC2893521 Disease Relevance 0.45 Pain Relevance 0

General Comments

This test has worked.

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