INT204355

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.26
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 1 91.60 High High
antagonist 4 77.80 Quite High
agonist 11 66.60 Quite High
bDMF 21 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 98.80 Very High Very High Very High
Myeloproliferative Disorder 1 90.96 High High
Disease 136 85.52 High High
Death 10 85.40 High High
Myelodysplastic Syndromes 4 84.00 Quite High
Chronic Lymphoid Leukemia 14 83.64 Quite High
Leukemia 52 79.12 Quite High
Lymphatic System Cancer 25 74.88 Quite High
Apoptosis 60 74.24 Quite High
Myeloid Leukemia 28 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rodents, knockout of the eNOS gene abolishes the caloric restriction-induced expression of PPARGC1A and TFAM mRNA and mitochondrial protein content [7].
Transcription (expression) of TFAM associated with targeted disruption
1) Confidence 0.63 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.10 Pain Relevance 0
The hub genes included those encoding general transcription factor iiic, polypeptide 1, alpha 220 kda (GTF3C1), which is involved in RNA polymerase III-mediated transcription, microtubule-associated protein 4 (MAP4), which promotes microtubule stability and affects cell growth [28], and proprotein convertase subtilisin/kexin type 2 (PC2), which is responsible for the processing of neuropeptide precursors.
Transcription (transcription) of transcription factor associated with neuropeptide
2) Confidence 0.11 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.85 Pain Relevance 0.05
reduction in erythroid lineage-transcription factor, GATA-1, levels [180].
Transcription (transcription factor) of transcription factor
3) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.32 Pain Relevance 0.07

General Comments

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