INT204361

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1)
nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)
Anatomy Link Frequency
body 1
SIRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overweight 6 96.36 Very High Very High Very High
Stress 10 84.72 Quite High
Obesity 11 28.00 Quite Low
Aging 8 5.00 Very Low Very Low Very Low
Weight Loss 2 5.00 Very Low Very Low Very Low
Chronic Disease 2 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Helminth Infection 1 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show, to our knowledge for the first time, that in overweight nonobese humans, short-term caloric restriction lowers whole-body energy expenditure (metabolic adaptation), in parallel with an induction in mitochondrial biogenesis, PPARGC1A and SIRT1 mRNA, and a decrease in DNA damage.
Negative_regulation (decrease) of SIRT1 in body associated with overweight
1) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.18 Pain Relevance 0

General Comments

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