INT204365

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.90
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1)
nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)
Anatomy Link Frequency
brain 4
fat 2
skeletal muscle 2
myotubes 2
liver 1
SIRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 97.28 Very High Very High Very High
tolerance 1 96.00 Very High Very High Very High
Hippocampus 13 69.44 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 97.28 Very High Very High Very High
Impaired Glucose Tolerance 1 96.32 Very High Very High Very High
Apoptosis 69 94.68 High High
Obesity 55 81.60 Quite High
Cognitive Disorder 158 78.40 Quite High
Stress 73 72.56 Quite High
Insulin Resistance 3 68.08 Quite High
Aging 78 62.40 Quite High
Injury 2 61.48 Quite High
Neurodegenerative Disease 26 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our results indicate that NO can induce mitochondrial biogenesis in human skeletal muscle without increasing SIRT1 protein expression.
Neg (without) Positive_regulation (increasing) of Gene_expression (expression) of SIRT1 protein in skeletal muscle
1) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
In rodents, the expression of SIRT1 is increased in response to prolonged caloric restriction in adipose, liver, kidney, and brain tissue [7,54].
Positive_regulation (increased) of Gene_expression (expression) of SIRT1 in brain
2) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0
Furthermore, in the present study we demonstrate, for the first time, that SIRT1 mRNA expression increases after marathon (Figure 6).
Positive_regulation (increases) of Gene_expression (expression) of SIRT1 mRNA
3) Confidence 0.60 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.70 Pain Relevance 0
It is therefore very likely that increased SIRT1 expression by endurance exercise results in elevated SIRT1 deacetylase activity as well as causing an allosteric effect of an increased cytosolic NAD+-to-NADH ratio.
Positive_regulation (increased) of Gene_expression (expression) of SIRT1
4) Confidence 0.60 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.69 Pain Relevance 0
In primary cultures of human myotubes, a nitric oxide donor (mimicking eNOS signaling) induced mitochondrial biogenesis but failed to induce SIRT1 protein expression, suggesting that additional factors may regulate SIRT1 content during CR.


Neg (failed) Positive_regulation (induce) of Gene_expression (expression) of SIRT1 protein in myotubes
5) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
Mice with overexpression of SIRT1 showed fewer consequences of a high fat diet – lower lipid-induced inflammation and better glucose tolerance (Pfluger et al., 2008).
Positive_regulation (overexpression) of Gene_expression (overexpression) of SIRT1 in fat associated with inflammation, tolerance and impaired glucose tolerance
6) Confidence 0.33 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2999838 Disease Relevance 0.73 Pain Relevance 0.13
In rodents, the expression of SIRT1 is increased in response to prolonged caloric restriction in adipose, liver, kidney, and brain tissue [7,54].
Positive_regulation (increased) of in liver Gene_expression (expression) of SIRT1 in brain
7) Confidence 0.23 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0
In rodents, the expression of SIRT1 is increased in response to prolonged caloric restriction in adipose, liver, kidney, and brain tissue [7,54].
Positive_regulation (increased) of in kidney Gene_expression (expression) of SIRT1 in brain
8) Confidence 0.23 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0

General Comments

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