INT204365

Context Info Confidence 0.68 First Reported 2007 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 2.90 Pain Relevance 0.13

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1) nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)

Anatomy Link Frequency brain 4 fat 2 skeletal muscle 2 myotubes 2 liver 1 SIRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 1 97.28 tolerance 1 96.00 Hippocampus 13 69.44 anesthesia 6 5.00 alcohol 6 5.00 imagery 6 5.00 Dopamine 2 5.00 Analgesic 2 5.00 cINOD 2 5.00 addiction 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 3 97.28 Impaired Glucose Tolerance 1 96.32 Apoptosis 69 94.68 Obesity 55 81.60 Cognitive Disorder 158 78.40 Stress 73 72.56 Insulin Resistance 3 68.08 Aging 78 62.40 Injury 2 61.48 Neurodegenerative Disease 26 60.64

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Event

Anatomy

Negation

Speculation

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Disease term

However, our results indicate that NO can induce mitochondrial biogenesis in human skeletal muscle without increasing SIRT1 protein expression.

Neg (without) Positive_regulation (increasing) of Gene_expression (expression) of SIRT1 protein in skeletal muscle

1) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0

In rodents, the expression of SIRT1 is increased in response to prolonged caloric restriction in adipose, liver, kidney, and brain tissue [7,54].

Positive_regulation (increased) of Gene_expression (expression) of SIRT1 in brain

2) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0

Furthermore, in the present study we demonstrate, for the first time, that SIRT1 mRNA expression increases after marathon (Figure 6).

Positive_regulation (increases) of Gene_expression (expression) of SIRT1 mRNA

3) Confidence 0.60 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.70 Pain Relevance 0

It is therefore very likely that increased SIRT1 expression by endurance exercise results in elevated SIRT1 deacetylase activity as well as causing an allosteric effect of an increased cytosolic NAD+-to-NADH ratio.

Positive_regulation (increased) of Gene_expression (expression) of SIRT1

4) Confidence 0.60 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.69 Pain Relevance 0

In primary cultures of human myotubes, a nitric oxide donor (mimicking eNOS signaling) induced mitochondrial biogenesis but failed to induce SIRT1 protein expression, suggesting that additional factors may regulate SIRT1 content during CR.

Neg (failed) Positive_regulation (induce) of Gene_expression (expression) of SIRT1 protein in myotubes

5) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0

Mice with overexpression of SIRT1 showed fewer consequences of a high fat diet – lower lipid-induced inflammation and better glucose tolerance (Pfluger et al., 2008).

Positive_regulation (overexpression) of Gene_expression (overexpression) of SIRT1 in fat associated with inflammation, tolerance and impaired glucose tolerance

6) Confidence 0.33 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2999838 Disease Relevance 0.73 Pain Relevance 0.13

In rodents, the expression of SIRT1 is increased in response to prolonged caloric restriction in adipose, liver, kidney, and brain tissue [7,54].

Positive_regulation (increased) of in liver Gene_expression (expression) of SIRT1 in brain

7) Confidence 0.23 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0

In rodents, the expression of SIRT1 is increased in response to prolonged caloric restriction in adipose, liver, kidney, and brain tissue [7,54].

Positive_regulation (increased) of in kidney Gene_expression (expression) of SIRT1 in brain

8) Confidence 0.23 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0

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