INT204367

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1)
nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)
Anatomy Link Frequency
skeletal muscle 1
myotubes 1
body 1
SIRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 13 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 88 99.72 Very High Very High Very High
Aging 105 99.16 Very High Very High Very High
Stress 116 98.12 Very High Very High Very High
Myeloid Leukemia 62 98.10 Very High Very High Very High
Overweight 49 97.40 Very High Very High Very High
Heart Disease 10 90.52 High High
Cancer 25 88.68 High High
Apoptosis 122 88.60 High High
Cognitive Disorder 158 79.08 Quite High
Targeted Disruption 8 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SIRT1 mRNA was increased in the CR (113% ± 24%; p = 0.016) and CREX groups (61% ± 8%; p = 0.023) (Figure 1C).
Positive_regulation (increased) of SIRT1
1) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.10 Pain Relevance 0
In murine white adipocytes NO treatment increases SIRT1 protein [7], suggesting eNOS may also be involved in regulating SIRT1 in skeletal muscle.
Positive_regulation (increases) of SIRT1 protein in skeletal muscle associated with obesity
2) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.10 Pain Relevance 0
In support of this concept, SIRT1 mRNA was increased in the CR and CREX groups in proportion to the increase in PPARGC1A mRNA, consistent with the potential role of SIRT1 as a direct regulator of PPARGC1A activity [11,14].
Positive_regulation (increased) of SIRT1
3) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0
This might be expected to change SIRT1 activity and gene transcription.
Positive_regulation (change) of SIRT1
4) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.12 Pain Relevance 0
Consistently, adiponectin-mediated signaling increased SIRT1 protein in primary human myotubes.
Positive_regulation (increased) of SIRT1 protein in myotubes
5) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.12 Pain Relevance 0
We observed a smaller induction in mitochondrial biogenesis and SIRT1 mRNA in the CREX relative to CR group.
Positive_regulation (induction) of SIRT1
6) Confidence 0.68 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0
It is therefore very likely that increased SIRT1 expression by endurance exercise results in elevated SIRT1 deacetylase activity as well as causing an allosteric effect of an increased cytosolic NAD+-to-NADH ratio.
Positive_regulation (elevated) of SIRT1
7) Confidence 0.60 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.63 Pain Relevance 0
In addition, an increase in SIRT1 mRNA levels could exert an antioxidant effect.
Positive_regulation (increase) of SIRT1 mRNA
8) Confidence 0.60 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.49 Pain Relevance 0
We show, to our knowledge for the first time, that in overweight nonobese humans, short-term caloric restriction lowers whole-body energy expenditure (metabolic adaptation), in parallel with an induction in mitochondrial biogenesis, PPARGC1A and SIRT1 mRNA, and a decrease in DNA damage.
Positive_regulation (induction) of SIRT1 in body associated with overweight
9) Confidence 0.49 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.18 Pain Relevance 0
Resveratrol has been hypothesized to activate the SIRT1 gene which has a role in longevity across a large range of species (Browner et al., 2004).
Positive_regulation (activate) of SIRT1 gene associated with aging
10) Confidence 0.33 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2999838 Disease Relevance 0.83 Pain Relevance 0
Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05).
Positive_regulation (increased) of SIRT1
11) Confidence 0.20 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.22 Pain Relevance 0
However, the literature shows that Resveratrol-induced ERK activation may happen through induction of sirtuin SIRT1 (silent mating type information regulation 2 homolog) by Resveratrol [35].
Positive_regulation (induction) of SIRT1
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.06 Pain Relevance 0
In addition, analyses of the expression and functional activity of HDACs and HATs in the imatinib resistant CML cell line K562 have indicated that Class I (HDAC1, 2 and 3), Class IIA (HDAC4) and Class III (SIRT1) HDACs are all elevated and increased compared to imatinib sensitive cells, whereas the levels of HATs are decreased [12, 74].
Positive_regulation (elevated) of SIRT1 associated with myeloid leukemia
13) Confidence 0.14 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.59 Pain Relevance 0
In addition, analyses of the expression and functional activity of HDACs and HATs in the imatinib resistant CML cell line K562 have indicated that Class I (HDAC1, 2 and 3), Class IIA (HDAC4) and Class III (SIRT1) HDACs are all elevated and increased compared to imatinib sensitive cells, whereas the levels of HATs are decreased [12, 74].
Positive_regulation (increased) of SIRT1 associated with myeloid leukemia
14) Confidence 0.14 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.59 Pain Relevance 0

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