INT204368

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Context Info
Confidence 0.76
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 4.48
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1)
nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)
Anatomy Link Frequency
skeletal muscle 2
fat 1
liver 1
brain 1
myotubes 1
SIRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 97.28 Very High Very High Very High
tolerance 1 96.00 Very High Very High Very High
alcohol 20 90.64 High High
Hippocampus 13 69.44 Quite High
cINOD 8 61.52 Quite High
anesthesia 10 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 199 99.52 Very High Very High Very High
INFLAMMATION 8 97.28 Very High Very High Very High
Impaired Glucose Tolerance 1 96.32 Very High Very High Very High
Shock 7 87.24 High High
Chronic Disease 16 82.48 Quite High
Obesity 88 81.16 Quite High
Cognitive Disorder 158 78.40 Quite High
Weight Loss 16 78.08 Quite High
Overweight 49 75.84 Quite High
Stress 169 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rodents, the expression of SIRT1 is increased in response to prolonged caloric restriction in adipose, liver, kidney, and brain tissue [7,54].
Gene_expression (expression) of SIRT1 in brain
1) Confidence 0.76 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0
The change in eNOS mRNA from baseline was highly correlated with the change in the expression of PPARGC1A and SIRT1 in the CR group (r = 0.86, p < 0.001 and r = 0.80, p < 0.001, respectively; unpublished data), suggesting synergistic regulation among PPARGC1A, SIRT1, and eNOS.
Gene_expression (expression) of SIRT1
2) Confidence 0.76 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0
Currently, there no data in human skeletal muscle on how caloric restriction may affect the expression of PPARGC1A and SIRT1, as well as mitochondrial number and function.
Gene_expression (expression) of SIRT1 in skeletal muscle
3) Confidence 0.76 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.29 Pain Relevance 0
However, our results indicate that NO can induce mitochondrial biogenesis in human skeletal muscle without increasing SIRT1 protein expression.
Gene_expression (expression) of SIRT1 protein in skeletal muscle
4) Confidence 0.76 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
It is therefore very likely that increased SIRT1 expression by endurance exercise results in elevated SIRT1 deacetylase activity as well as causing an allosteric effect of an increased cytosolic NAD+-to-NADH ratio.
Gene_expression (expression) of SIRT1
5) Confidence 0.67 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.64 Pain Relevance 0
Furthermore, in the present study we demonstrate, for the first time, that SIRT1 mRNA expression increases after marathon (Figure 6).
Gene_expression (expression) of SIRT1 mRNA
6) Confidence 0.67 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.70 Pain Relevance 0
In primary cultures of human myotubes, a nitric oxide donor (mimicking eNOS signaling) induced mitochondrial biogenesis but failed to induce SIRT1 protein expression, suggesting that additional factors may regulate SIRT1 content during CR.


Gene_expression (expression) of SIRT1 protein in myotubes
7) Confidence 0.59 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
These data indicate that adiponectin signaling may be involved in the regulation of SIRT1-PPARGC1A protein expression.
Gene_expression (expression) of SIRT1
8) Confidence 0.59 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.12 Pain Relevance 0
These data suggest that the physiological load imposed in amateur runners during marathon attenuates the extent of apoptosis and may interfere with sirtuin expression.



Gene_expression (expression) of sirtuin associated with apoptosis
9) Confidence 0.58 Published 2010 Journal BMC Physiol Section Abstract Doc Link PMC2893521 Disease Relevance 0.45 Pain Relevance 0
The expression of Sirt2, a member of the Drosophila Sirtuin family [95], was strongly decreased in the mub, BG00817 and esg mutant backgrounds.
Gene_expression (expression) of Sirtuin
10) Confidence 0.58 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912381 Disease Relevance 0.14 Pain Relevance 0.05
SIRT1, SIRT3 and SIRT4 levels
Gene_expression (levels) of SIRT1
11) Confidence 0.58 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0 Pain Relevance 0
In addition, Northern blot analysis showed that RNA levels of the SIRT1-dependent transcription factor FOXO3A and its target GADD45 were increased in the studied group after marathon (Figure 7).
Gene_expression (levels) of SIRT1
12) Confidence 0.52 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.07 Pain Relevance 0
Strenuous physical load significantly increased HSP70, HSP32, Mn-SOD, Cu-Zn SOD, iNOS, GADD45, bcl-2, forkhead box O (FOXO3A) and SIRT1 expression after the marathon, while decreasing bax, SIRT3 and SIRT4 expression (P < 0.0001).


Gene_expression (expression) of SIRT1
13) Confidence 0.52 Published 2010 Journal BMC Physiol Section Abstract Doc Link PMC2893521 Disease Relevance 0.38 Pain Relevance 0
Mice with overexpression of SIRT1 showed fewer consequences of a high fat diet – lower lipid-induced inflammation and better glucose tolerance (Pfluger et al., 2008).
Gene_expression (overexpression) of SIRT1 in fat associated with inflammation, tolerance and impaired glucose tolerance
14) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2999838 Disease Relevance 0.73 Pain Relevance 0.13
In rodents, the expression of SIRT1 is increased in response to prolonged caloric restriction in adipose, liver, kidney, and brain tissue [7,54].
Gene_expression (expression) of SIRT1 in liver
15) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0
In rodents, the expression of SIRT1 is increased in response to prolonged caloric restriction in adipose, liver, kidney, and brain tissue [7,54].
Gene_expression (expression) of SIRT1 in kidney
16) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0
The other compound identified in the CMAP analysis, resveratrol, was recently shown to activate SIRT1, which promotes the deacetylation of ?
Gene_expression (activate) of SIRT1
17) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.12 Pain Relevance 0.12

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