INT204370

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.82
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
skeletal muscle 2
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 41 89.84 High High
Inflammation 17 50.00 Quite Low
Pain 15 50.00 Quite Low
anesthesia 2 43.36 Quite Low
Inflammatory stimuli 2 38.48 Quite Low
agonist 10 28.68 Quite Low
metalloproteinase 3 25.92 Quite Low
Bioavailability 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 15 93.52 High High
Osteoarthritis 41 89.84 High High
Disease 13 88.48 High High
Death 4 78.12 Quite High
Apoptosis 20 70.60 Quite High
Targeted Disruption 12 63.72 Quite High
Insulin Resistance 3 59.56 Quite High
Body Weight 4 55.56 Quite High
INFLAMMATION 21 50.00 Quite Low
Pain 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting assay for Cu/Zn superoxide dismutase
Negative_regulation (blotting) of Cu/Zn superoxide dismutase Binding (assay) of
1) Confidence 0.41 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.06 Pain Relevance 0
In addition, the activity of superoxide dismutase (SOD), a free radical scavenging enzyme that catalyzes the breakdown of ROS to hydrogen peroxide and molecular oxygen, tended to decrease in the skeletal muscle of the CR group (?
Negative_regulation (decrease) of SOD Binding (activity) of in skeletal muscle
2) Confidence 0.16 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.06 Pain Relevance 0
The increase in DNA damage was attenuated by incubation with the specific iNOS inhibitor 1400 W and the superoxide scavenger SOD, suggesting that superoxide may have a role in generating DNA breaks.
Negative_regulation (attenuated) of SOD Binding (incubation) of
3) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582805 Disease Relevance 0.55 Pain Relevance 0.13
A single amino-acid replacement (M560D) largely disrupted homodimer formation, resulting in severe behavioral and molecular phenotypes.
Negative_regulation (disrupted) of homodimer Binding (formation) of
4) Confidence 0.01 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2671555 Disease Relevance 0.16 Pain Relevance 0

General Comments

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