INT204446

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Context Info
Confidence 0.79
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fmr1) RNA binding (Fmr1) nucleus (Fmr1)
cytoplasm (Fmr1)
Anatomy Link Frequency
Mouse 1
nucleus 1
Fmr1 (Mus musculus)
Fmr1 - I304N (2)
Pain Link Frequency Relevance Heat
agonist 40 49.68 Quite Low
Hippocampus 12 20.44 Low Low
cerebral cortex 4 19.92 Low Low
Glutamate receptor 24 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 120 94.24 High High
Targeted Disruption 200 81.44 Quite High
Sprains And Strains 44 70.64 Quite High
Cognitive Disorder 16 67.84 Quite High
Repression 16 59.20 Quite High
Disease 36 59.12 Quite High
Alzheimer's Dementia 84 51.04 Quite High
Fragile X Syndrome 84 50.00 Quite Low
Tremor 4 32.72 Quite Low
Ataxia 4 32.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon mGluR activation, FMRP is released from the nontranslating RNP, resulting in prompt protein synthesis.
Localization (released) of FMRP
1) Confidence 0.79 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.34 Pain Relevance 0
Immunoprecipitation of FMRP from WT SNs followed by Western blotting (Figure 6B) or 35S-Met incorporation analysis (unpublished data) demonstrated that DHPG treatment does not interfere with the ability of anti–7G1–1 antibody to bind to FMRP.
Localization (Immunoprecipitation) of FMRP
2) Confidence 0.74 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.20 Pain Relevance 0
Western blotting of a duplicate membrane indicated that FMRP migrates at 80 kDa.
Localization (migrates) of FMRP
3) Confidence 0.69 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.27 Pain Relevance 0
Finally, FMRP has a nuclear localization signal (NLS) mapped to approximately 100 nucleotides of the N-terminus [47], and a Rev-like nuclear export signal (NES) C-terminal to the KH domains, which, when mutated at critical leucines, causes accumulation of FMRP in the nucleus [48].
Localization (accumulation) of FMRP in nucleus
4) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
Here we address these issues by generating and analyzing a mouse (Fmr1tm1(I304N)Drnl, termed here Fmr1I304N) harboring the I304N mutation.
Localization (termed) of Fmr1tm1 (I304N)
5) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.12 Pain Relevance 0
Mouse brain I304N FMRP retains some functional domains
Localization (Mouse) of brain I304N FMRP (I304N) in Mouse
6) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
Here we address these issues by generating and analyzing a mouse (Fmr1tm1(I304N)Drnl, termed here Fmr1I304N) harboring the I304N mutation.
Localization (termed) of Fmr1I304N
7) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.13 Pain Relevance 0
Therefore, we prepared cortical lysates as well as SNs from WT mice and immunoprecipitated FMRP.
Localization (immunoprecipitated) of FMRP
8) Confidence 0.64 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.05 Pain Relevance 0

General Comments

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