INT204452

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.48
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fxr1) RNA binding (Fxr1) nucleus (Fxr1)
cytoplasm (Fxr1)
Anatomy Link Frequency
brain 2
liver 1
cerebral cortex 1
cerebellum 1
hippocampus 1
Fxr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 15 99.04 Very High Very High Very High
cerebral cortex 3 98.78 Very High Very High Very High
Inflammation 116 67.60 Quite High
Inflammatory stimuli 3 64.88 Quite High
cINOD 5 44.96 Quite Low
cytokine 33 37.28 Quite Low
agonist 51 5.00 Very Low Very Low Very Low
Glutamate receptor 24 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 101 99.54 Very High Very High Very High
Liver Disease 30 97.40 Very High Very High Very High
Intellectual Impairment 73 93.88 High High
Frailty 1 93.16 High High
Autism 42 92.96 High High
Targeted Disruption 183 92.04 High High
Fragile X Syndrome 126 91.36 High High
Disease 63 90.56 High High
Sprains And Strains 39 90.28 High High
Starvation 2 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found that the I304N mutation in FMRP does not significantly affect FXR1P or FXR2P polyribosome association in mouse brain (Figure 5A), suggesting that their polysome-association is not FMRP-dependent.
FXR1P Neg (not) Binding (association) of in brain
1) Confidence 0.40 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
This is consistent with our observation that I304N-FMRP in mouse brain fails to crosslink to kcRNA, but retains other activities, including the ability to crosslink to G-quartet RNA and to heterodimerize with FXR1P and FXR2P (Figure 7).
FXR1P Binding (heterodimerize) of in brain
2) Confidence 0.31 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
Protein interaction domains include an N-terminal region responsible for homodimerization and heterodimerization with its autosomal homologs FXR1P and FXR2P [45],[46].
FXR1P Binding (heterodimerization) of
3) Confidence 0.30 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
Moreover, FMRP, and the related protein FXR1P, associate with components of the RNA-induced silencing complex (RISC) in Drosophila and mammalian cells [29]–[32], and FXR1P is required to mediate miRNA-dependent translational activation in tissue culture cells [33],[34].
FXR1P Binding (associate) of
4) Confidence 0.30 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.19 Pain Relevance 0
The potential importance of single patient with a missense mutation (I304N) in an RNA–binding domain of the Fragile X protein, FMRP, has been questioned in part because he has a confounding liver disease.
Fragile X protein Binding (binding) of in liver associated with liver disease
5) Confidence 0.30 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2779495 Disease Relevance 0.96 Pain Relevance 0
In vitro studies indicated that I304N FMRP retains the ability to heterodimerize with FXR1P and FXR2P [63].
FXR1P Binding (heterodimerize) of
6) Confidence 0.30 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
There are increased APP mRNA levels in the cerebral cortex, hippocampus, and cerebellum in a FXS mouse model [32], and FXR1P, an FMRP homolog, is an AU-rich element–binding protein that binds to and regulates TNF?
FXR1P Binding (binds) of in cerebellum associated with syndrome, hippocampus and cerebral cortex
7) Confidence 0.29 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.69 Pain Relevance 0.10
A recent review describes in detail the role of the miRNP (microribonucleoprotein)-associated proteins FXR1 and Argonaute 2 as effector molecules that bind the ARE to activate TNF-?
FXR1 Binding (bind) of
8) Confidence 0.22 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.27 Pain Relevance 0.15
There are increased APP mRNA levels in the cerebral cortex, hippocampus, and cerebellum in a FXS mouse model [32], and FXR1P, an FMRP homolog, is an AU-rich element–binding protein that binds to and regulates TNF?
FXR1P Binding (binds) of in cerebral cortex associated with syndrome, hippocampus and cerebral cortex
9) Confidence 0.10 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.69 Pain Relevance 0.10
There are increased APP mRNA levels in the cerebral cortex, hippocampus, and cerebellum in a FXS mouse model [32], and FXR1P, an FMRP homolog, is an AU-rich element–binding protein that binds to and regulates TNF?
FXR1P Binding (binds) of in hippocampus associated with syndrome, hippocampus and cerebral cortex
10) Confidence 0.10 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.69 Pain Relevance 0.10

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