INT204461

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.58
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn10a) plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
joint 1
Scn10a (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 24 99.88 Very High Very High Very High
Inflammation 103 97.80 Very High Very High Very High
Neurotransmitter 10 92.80 High High
tetrodotoxin 4 82.56 Quite High
rheumatoid arthritis 12 72.48 Quite High
agonist 31 65.68 Quite High
Inflammatory response 4 40.28 Quite Low
chemokine 3 36.40 Quite Low
cytokine 14 35.80 Quite Low
halothane 4 21.20 Low Low
Disease Link Frequency Relevance Heat
Disease 11 99.96 Very High Very High Very High
Experimental Arthritis 7 99.88 Very High Very High Very High
Targeted Disruption 166 98.72 Very High Very High Very High
Arthritis 24 98.04 Very High Very High Very High
Immunization 1 96.64 Very High Very High Very High
Syndrome 108 96.48 Very High Very High Very High
Alzheimer's Dementia 84 91.36 High High
INFLAMMATION 102 85.84 High High
Neurogenic Inflammation 2 80.52 Quite High
Synovitis 5 73.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Radiolabeling SNs with 35S-Met and immunoprecipitation of APP.
Localization (immunoprecipitation) of SNs
1) Confidence 0.31 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.20 Pain Relevance 0.08
Immunoprecipitation of FMRP from WT SNs followed by Western blotting (Figure 6B) or 35S-Met incorporation analysis (unpublished data) demonstrated that DHPG treatment does not interfere with the ability of anti–7G1–1 antibody to bind to FMRP.
Localization (Immunoprecipitation) of SNs
2) Confidence 0.31 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.20 Pain Relevance 0
Aliquots of SNs were collected at the indicated timepoints and flash frozen at ?
Localization (Aliquots) of SNs
3) Confidence 0.31 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.09 Pain Relevance 0
Cortical SNs were prepared from both WT and fmr-1 KO mice, and overall protein synthesis was analyzed in response to DHPG (100 ?
Spec (analyzed) Localization (Cortical) of SNs associated with targeted disruption
4) Confidence 0.31 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.43 Pain Relevance 0
In the late stages of experimental arthritis, the SNS markedly decreases disease activity, and sympathectomy exacerbates joint inflammation [40].
Localization (decreases) of SNS in joint associated with inflammation, disease, experimental arthritis and arthritis
5) Confidence 0.08 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2927688 Disease Relevance 1.65 Pain Relevance 0.71

General Comments

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