INT204467

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 1.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fmr1) RNA binding (Fmr1) nucleus (Fmr1)
cytoplasm (Fmr1)
Anatomy Link Frequency
dendrites 2
Fmr1 (Mus musculus)
Fmr1 - I304N (2)
Pain Link Frequency Relevance Heat
agonist 41 5.00 Very Low Very Low Very Low
Glutamate receptor 18 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fragile X Syndrome 105 97.12 Very High Very High Very High
Repression 8 97.08 Very High Very High Very High
Targeted Disruption 127 89.20 High High
Disease 45 80.32 Quite High
Liver Disease 25 75.72 Quite High
Aging 6 75.52 Quite High
Autism 32 75.44 Quite High
Intellectual Impairment 57 74.56 Quite High
Alzheimer's Dementia 42 50.00 Quite Low
Syndrome 69 41.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presumably, the loss of FMRP/APP mRNA interaction results in rapid, pulsatile protein expression in dendrites.


Negative_regulation (loss) of FMRP Binding (interaction) of in dendrites
1) Confidence 0.57 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.15 Pain Relevance 0
These data suggest that loss of FMRP function, particularly in KH2-mediated RNA binding and in synaptic plasticity, play critical roles in pathogenesis of the Fragile X Syndrome and establish a new model for studying the disorder.


Negative_regulation (loss) of FMRP Binding (binding) of associated with fragile x syndrome
2) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2779495 Disease Relevance 0.84 Pain Relevance 0
I304N FMRP is defective in polyribosome association and RNA binding
Negative_regulation (defective) of I304N FMRP (I304N) Binding (binding) of
3) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
I304N FMRP is defective in polyribosome association and RNA binding
Negative_regulation (defective) of I304N FMRP (I304N) Binding (association) of
4) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
This finding suggests that loss of FMRP activity, including but not necessarily limited to KH2 RNA binding, may play a critical role in leading to the synaptic defects evident in the mouse, and, presumably, in human patients.
Negative_regulation (loss) of FMRP Binding (binding) of
5) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
Therefore a major biochemical defect in the Fmr1I304N mouse is the loss of KH2-dependent RNA binding.
Negative_regulation (loss) of Fmr1I304N Binding (binding) of
6) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.15 Pain Relevance 0
The loss of FMRP binding at the G-rich region presumably derepresses APP translation, as it was contemporaneous.


Negative_regulation (loss) of FMRP Binding (binding) of
7) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.30 Pain Relevance 0

General Comments

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