INT204478

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.44
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Fmr1, App) transport (Fmr1) Golgi apparatus (App)
extracellular matrix organization (App) DNA binding (App) RNA binding (Fmr1)
Anatomy Link Frequency
neurons 2
Fmr1 (Mus musculus)
App (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 95.84 Very High Very High Very High
cerebral cortex 3 75.84 Quite High
Hippocampus 3 74.48 Quite High
Glutamate receptor 12 69.20 Quite High
tetrodotoxin 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 63 98.80 Very High Very High Very High
Targeted Disruption 123 98.40 Very High Very High Very High
Sprains And Strains 27 97.12 Very High Very High Very High
Syndrome 81 96.16 Very High Very High Very High
Repression 12 46.16 Quite Low
Intellectual Impairment 18 25.80 Quite Low
Autism 18 5.00 Very Low Very Low Very Low
Aging 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we hypothesized that APP mRNA translation would be regulated by FMRP.
FMRP Regulation (regulated) of Gene_expression (translation) of APP mRNA
1) Confidence 0.50 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.25 Pain Relevance 0.08
Therefore, we asked if APP translation was regulated by dendritic FMRP.
FMRP Spec (asked) Regulation (regulated) of Gene_expression (translation) of APP
2) Confidence 0.44 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.38 Pain Relevance 0
These data also demonstrate that FMRP and mGluR activation regulate APP synthesis in both FVB and C57BL/6 mice, as the SNs were prepared from the former strain, and the primary cortical neurons from the latter strain.


FMRP Regulation (regulate) of Gene_expression (synthesis) of APP in neurons associated with sprains and strains
3) Confidence 0.30 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.80 Pain Relevance 0.08

General Comments

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