INT204480

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fmr1, Scn10a) RNA binding (Fmr1) plasma membrane (Scn10a)
nucleus (Fmr1) transmembrane transport (Scn10a) cytoplasm (Fmr1)
Fmr1 (Mus musculus)
Scn10a (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 41 96.92 Very High Very High Very High
Alzheimer's Dementia 21 50.00 Quite Low
Syndrome 27 9.96 Low Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Autism 6 5.00 Very Low Very Low Very Low
Intellectual Impairment 6 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that APP mRNA is translationally repressed by FMRP in unstimulated WT SNs. mGluR activation rapidly derepresses APP synthesis as shown for FMRP and PSD-95 [21,22].
FMRP Negative_regulation (repressed) of Positive_regulation (unstimulated) of SNs
1) Confidence 0.17 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.74 Pain Relevance 0

General Comments

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