INT204489

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.71
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Fmr1, App) transport (Fmr1) Golgi apparatus (App)
extracellular matrix organization (App) DNA binding (App) RNA binding (Fmr1)
Fmr1 (Mus musculus)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 4 99.12 Very High Very High Very High
agonist 3 85.16 High High
tetrodotoxin 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 41 97.04 Very High Very High Very High
Alzheimer's Dementia 21 96.44 Very High Very High Very High
Sprains And Strains 9 96.32 Very High Very High Very High
Syndrome 27 95.16 Very High Very High Very High
Neurological Disease 1 82.72 Quite High
Cognitive Disorder 2 76.88 Quite High
Intellectual Impairment 6 72.20 Quite High
Neurodegenerative Disease 3 25.00 Low Low
Autism 6 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicate that postsynaptic FMRP binds to and regulates the translation of APP mRNA through metabotropic glutamate receptor activation and suggests a possible link between Alzheimer disease and fragile X syndrome.


FMRP Regulation (regulates) of APP mRNA associated with syndrome, glutamate receptor and alzheimer's dementia
1) Confidence 0.50 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC1808499 Disease Relevance 1.71 Pain Relevance 0.13

General Comments

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