INT204494

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2007
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 4.39
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (App, Fmr1) transport (Fmr1) Golgi apparatus (App)
extracellular matrix organization (App) DNA binding (App) cell adhesion (App)
Anatomy Link Frequency
dendrites 2
App (Mus musculus)
Fmr1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 42 96.92 Very High Very High Very High
Glutamate receptor 56 96.60 Very High Very High Very High
Hippocampus 14 55.36 Quite High
cerebral cortex 14 54.84 Quite High
tetrodotoxin 14 5.00 Very Low Very Low Very Low
halothane 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 574 99.60 Very High Very High Very High
Syndrome 378 99.20 Very High Very High Very High
Repression 56 99.04 Very High Very High Very High
Intellectual Impairment 84 95.20 Very High Very High Very High
Alzheimer's Dementia 294 91.72 High High
Sprains And Strains 126 87.52 High High
Neurological Disease 14 57.92 Quite High
Cognitive Disorder 28 52.08 Quite High
Tremor 14 25.44 Quite Low
Neurodegenerative Disease 42 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that FMRP binds to the coding region of APP mRNA at a guanine-rich, G-quartet–like sequence.
APP mRNA Binding (binds) of FMRP
1) Confidence 0.54 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC1808499 Disease Relevance 0.75 Pain Relevance 0.11
Our data suggest that multiple cis-regulatory elements of APP mRNA interact with the FMRP-containing RNP complex.


APP mRNA Binding (interact) of FMRP-containing
2) Confidence 0.54 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0 Pain Relevance 0
APP mRNA coimmunoprecipitated with FMRP in resting synaptoneurosomes, but the interaction was lost shortly after DHPG treatment.
APP mRNA Binding (coimmunoprecipitated) of FMRP
3) Confidence 0.54 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC1808499 Disease Relevance 1.24 Pain Relevance 0.13
However, APP mRNA associated with FMRP could not be detected in DHPG-stimulated WT SN immunopreciptates (IPs) or in the KO with or without DHPG within 40 cycles of real-time PCR.
APP mRNA Binding (associated) of FMRP associated with targeted disruption
4) Confidence 0.54 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.24 Pain Relevance 0
When FMRP is bound to APP or other synaptic mRNAs, translation is repressed.
APP Binding (bound) of FMRP
5) Confidence 0.47 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.26 Pain Relevance 0
Despite the presence of an RNase-protected, G-rich sequence, APP mRNA might not associate directly with FMRP.
APP mRNA Spec (might) Binding (associate) of FMRP
6) Confidence 0.47 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0 Pain Relevance 0
We asked if the APP mRNA/FMRP interaction changed after DHPG.
APP mRNA Spec (asked) Binding (interaction) of FMRP
7) Confidence 0.40 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.29 Pain Relevance 0.06
Presumably, the loss of FMRP/APP mRNA interaction results in rapid, pulsatile protein expression in dendrites.


APP mRNA Binding (interaction) of FMRP in dendrites
8) Confidence 0.40 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.15 Pain Relevance 0
APP mRNA coimmunoprecipitated with FMRP in WT, resting SNs, but this interaction was lost with DHPG treatment.
APP mRNA Binding (coimmunoprecipitated) of FMRP
9) Confidence 0.40 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.36 Pain Relevance 0.10
Our data indicate that FMRP represses the translation of APP through mGluR-dependent interactions with APP mRNA.
APP mRNA Binding (interactions) of FMRP
10) Confidence 0.40 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.42 Pain Relevance 0.08
We asked if the APP mRNA/FMRP interaction changed after DHPG.
APP mRNA Spec (asked) Binding (interaction) of FMRP
11) Confidence 0.40 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.29 Pain Relevance 0.06
Presumably, the loss of FMRP/APP mRNA interaction results in rapid, pulsatile protein expression in dendrites.


APP mRNA Binding (interaction) of FMRP in dendrites
12) Confidence 0.40 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.15 Pain Relevance 0
Our data suggest that physical interactions between FMRP and APP mRNA underlie translational repression, with mGluR activation rapidly moderating these events.
APP mRNA Binding (interactions) of FMRP associated with repression
13) Confidence 0.40 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.16 Pain Relevance 0
We have determined that FMRP associates with APP mRNA in SN preparations, and that translation of APP mRNA increases in response to DHPG.
APP mRNA Binding (associates) of FMRP
14) Confidence 0.40 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.07 Pain Relevance 0

General Comments

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