INT204524

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 11.69
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR9) signal transduction (TLR9) extracellular region (TLR9)
endoplasmic reticulum (TLR9) plasma membrane (TLR9) intracellular (TLR9)
Anatomy Link Frequency
Plasmacytoid dendritic cells 3
poly 1
leukocytes 1
B cells 1
epithelium 1
TLR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 86 98.52 Very High Very High Very High
Inflammation 235 91.96 High High
chemokine 24 90.76 High High
cytokine 178 90.20 High High
ischemia 7 86.92 High High
agonist 61 83.28 Quite High
Central nervous system 54 79.88 Quite High
Inflammatory response 42 79.44 Quite High
Paracetamol 3 71.92 Quite High
anesthesia 11 20.60 Low Low
Disease Link Frequency Relevance Heat
Hepatitis 9 99.74 Very High Very High Very High
Ventricular Remodeling 1 99.24 Very High Very High Very High
Infection 302 99.10 Very High Very High Very High
Systemic Lupus Erythematosus 172 98.80 Very High Very High Very High
Recurrence 37 98.68 Very High Very High Very High
Demyelinating Disease 93 98.52 Very High Very High Very High
Hepatitis Virus Infection 2 98.52 Very High Very High Very High
Hypersensitivity 108 98.04 Very High Very High Very High
Overdose 1 97.48 Very High Very High Very High
Cancer 237 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both, full-length and cleaved forms of TLR9, however, are capable of binding ligand [44].
TLR9 Binding (binding) of
1) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.28 Pain Relevance 0.26
Analysis was performed for both extracellular (cell membrane) and intracellular occurrence of TLR9.
TLR9 Binding (occurrence) of
2) Confidence 0.37 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.29 Pain Relevance 0
Immunoreactivity for TLR9 was also seen in scattered intraepithelial and subepithelial leukocytes (Figure 2C).
TLR9 Binding (Immunoreactivity) of in leukocytes
3) Confidence 0.36 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.26 Pain Relevance 0
Immunoreactivity for TLR9 was seen in many different cell types within the epithelium and submucosa of the nose (Figure 2).
TLR9 Binding (Immunoreactivity) of in epithelium
4) Confidence 0.36 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.41 Pain Relevance 0
Bacteria genomic DNA is recognized by TLR9; bacteria flagella protein, flagellin, is recognized by TLR5 [3].
TLR9 Binding (recognized) of
5) Confidence 0.33 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.07 Pain Relevance 0.10
Mean fluorescence intensity ratio of TLR9 in different compartments and cell types
TLR9 Binding (ratio) of
6) Confidence 0.33 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.05 Pain Relevance 0
These cells express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.
Toll-like receptor 9 Binding (recognizes) of
7) Confidence 0.32 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.04 Pain Relevance 0.43
These cells express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.
TLR-9 Binding (recognizes) of
8) Confidence 0.32 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.04 Pain Relevance 0.43
We speculate that this phenomenon may be due to the internalization of cell surface TLR9 after binding to its ligand.
TLR9 Binding (binding) of
9) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.18 Pain Relevance 0.11
Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse

The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.

TLR-9 Binding (recognizes) of in Plasmacytoid dendritic cells associated with multiple sclerosis and recurrence
10) Confidence 0.24 Published 2011 Journal J Neuroinflammation Section Title Doc Link PMC3022734 Disease Relevance 1.04 Pain Relevance 0.27
Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse

The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.

Toll-like receptor 9 Binding (recognizes) of in Plasmacytoid dendritic cells associated with multiple sclerosis and recurrence
11) Confidence 0.24 Published 2011 Journal J Neuroinflammation Section Title Doc Link PMC3022734 Disease Relevance 1.04 Pain Relevance 0.27
TLR3, TLR8 and TLR9 are recognized by virus-derived double stranded RNA (poly-I:C), virus-derived single stranded RNA (ssRNA) and unmethylated CpG motifs, respectively.
TLR9 Binding (recognized) of in poly
12) Confidence 0.19 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.67 Pain Relevance 0.10
TLR7 and TLR9 recognize single-stranded viral RNA and microbial DNA, respectively.
TLR9 Binding (recognize) of
13) Confidence 0.16 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 1.10 Pain Relevance 0.08
Components of hepatitis viruses are ligands for TLR3, TLR7, TLR8 and TLR9, but not for TLR4.
TLR9 Neg (not) Binding (ligands) of associated with hepatitis
14) Confidence 0.12 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.84 Pain Relevance 0.52
The CpG motifs act through binding to toll-like receptor 9 (TLR-9) on B cells and plasmacytoid dendritic cells [10, 51, 52].
TLR-9 Binding (binding) of in plasmacytoid dendritic cells
15) Confidence 0.10 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.28 Pain Relevance 0
Stimulation of the appropriate TLR may induce and restore a potent innate and adaptive immune response which is usually dysfunctional in patients with CHC.20,35 To date, drugs that have an agonistic action with the TLR9 (CPG 10101 or Actilon) and TLR7 (ANA245 or Isatoribine) mimicking their function are under development for therapy of HCV infection.20,35
TLR9 Binding (action) of associated with hepatitis c virus infection and infection
16) Confidence 0.09 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731021 Disease Relevance 1.06 Pain Relevance 0.09
Toll-like receptor 9 (TLR9) recognizes the CpG motifs present in bacterial DNA.
TLR9 Binding (recognizes) of
17) Confidence 0.06 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.38 Pain Relevance 0.07
As mentioned above, expression of TLRs on IECs is generally low and some receptors such as TLR5 and TLR9 are located basolaterally, thus possibly preventing an interaction with PAMPs in the intestinal lumen [7].
TLR9 Binding (interaction) of in intestinal lumen
18) Confidence 0.06 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.06 Pain Relevance 0.04
Bacterial DNA has also a similar effect, binding to Toll-like receptor-9 [146].
Toll-like receptor-9 Binding (binding) of
19) Confidence 0.05 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC2039733 Disease Relevance 0.29 Pain Relevance 0
The CpG motifs act through binding to toll-like receptor 9 (TLR-9) on B cells and plasmacytoid dendritic cells [10, 51, 52].
TLR-9 Binding (binding) of in B cells
20) Confidence 0.03 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.28 Pain Relevance 0

General Comments

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