INT204525

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.80
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3)
intracellular (TLR3) cytoplasm (TLR3)
Anatomy Link Frequency
epithelial cells 2
endometrium 2
nasal epithelium 2
TLR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 63 99.38 Very High Very High Very High
cytokine 24 97.68 Very High Very High Very High
Inflammation 62 85.92 High High
pain pelvic 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 114 99.38 Very High Very High Very High
Endometriosis 36 89.76 High High
Conjunctivitis 3 87.04 High High
INFLAMMATION 62 85.92 High High
Infection 12 75.64 Quite High
Hypersensitivity 24 66.88 Quite High
Reprotox - General 3 12 52.48 Quite High
Necrosis 6 51.24 Quite High
Rhinitis 22 36.40 Quite Low
Hyperplasia 9 31.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, Th2 cytokines were shown to play an important role in balancing TLR signalling in human intestinal epithelial cells by mediating downregulation of TLR3 and TLR4 expression and function [42].
Negative_regulation (downregulation) of Gene_expression (expression) of TLR3 in epithelial cells associated with cytokine
1) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.67 Pain Relevance 0.34
Figure 4 exemplary presents the expression of TLR3 and TLR4 protein in eutopic compared to ectopic endometrium from the same patient.
Negative_regulation (presents) of Gene_expression (expression) of TLR3 in endometrium
2) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.43 Pain Relevance 0.11
In endometriosis, we can observe a significant decrease in TLR3 and TLR4 mRNA levels in eutopic tissues collected during the proliferative phase, when compared to controls (P < 0.05; figure 3A–B).
Negative_regulation (decrease) of Gene_expression (levels) of TLR3 associated with endometriosis
3) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.32 Pain Relevance 0.08
Previously, we reported an increased protein expression of TLR2, TLR3 and TLR4 in the nasal epithelium following allergen challenge [18].
Negative_regulation (reported) of Gene_expression (expression) of TLR3 in nasal epithelium
4) Confidence 0.19 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.38 Pain Relevance 0.07

General Comments

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