INT204525

Context Info Confidence 0.54 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 1.80 Pain Relevance 0.61

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3) intracellular (TLR3) cytoplasm (TLR3)

Anatomy Link Frequency epithelial cells 2 endometrium 2 nasal epithelium 2 TLR3 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 63 99.38 cytokine 24 97.68 Inflammation 62 85.92 pain pelvic 3 5.00 Dismenorea 3 5.00 anesthesia 2 5.00 corticosteroid 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat Endometriosis (extended) 114 99.38 Endometriosis 36 89.76 Conjunctivitis 3 87.04 INFLAMMATION 62 85.92 Infection 12 75.64 Hypersensitivity 24 66.88 Reprotox - General 3 12 52.48 Necrosis 6 51.24 Rhinitis 22 36.40 Hyperplasia 9 31.84

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, Th2 cytokines were shown to play an important role in balancing TLR signalling in human intestinal epithelial cells by mediating downregulation of TLR3 and TLR4 expression and function [42].

Negative_regulation (downregulation) of Gene_expression (expression) of TLR3 in epithelial cells associated with cytokine

1) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.67 Pain Relevance 0.34

Figure 4 exemplary presents the expression of TLR3 and TLR4 protein in eutopic compared to ectopic endometrium from the same patient.

Negative_regulation (presents) of Gene_expression (expression) of TLR3 in endometrium

2) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.43 Pain Relevance 0.11

In endometriosis, we can observe a significant decrease in TLR3 and TLR4 mRNA levels in eutopic tissues collected during the proliferative phase, when compared to controls (P < 0.05; figure 3A–B).

Negative_regulation (decrease) of Gene_expression (levels) of TLR3 associated with endometriosis

3) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.32 Pain Relevance 0.08

Previously, we reported an increased protein expression of TLR2, TLR3 and TLR4 in the nasal epithelium following allergen challenge [18].

Negative_regulation (reported) of Gene_expression (expression) of TLR3 in nasal epithelium

4) Confidence 0.19 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.38 Pain Relevance 0.07

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