INT204527

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.88
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR9) signal transduction (TLR9) extracellular region (TLR9)
endoplasmic reticulum (TLR9) plasma membrane (TLR9) intracellular (TLR9)
Anatomy Link Frequency
granulocytes 1
lymphocytes 1
fibroblasts 1
TLR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 87.40 High High
anesthesia 11 77.12 Quite High
Inflammation 94 43.84 Quite Low
Inflammatory response 26 26.80 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
chemokine 17 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 8 99.16 Very High Very High Very High
Insulin Resistance 10 98.36 Very High Very High Very High
Diabetes Mellitus 17 97.72 Very High Very High Very High
Hypersensitivity 98 97.12 Very High Very High Very High
Death 7 89.76 High High
Papillomavirus Infection 18 89.72 High High
Infection 34 88.48 High High
Cancer 1 87.64 High High
INFLAMMATION 122 87.00 High High
Mycobacterial Infection 4 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M CpG DNA, and CpG control DNA (target TLR9) and the activities of the p60 and p50 subunits of NF?
Regulation (activities) of TLR9
1) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
M CpG DNA, and CpG control DNA (target TLR9) and the activities of the p60 and p50 subunits of NF?
Regulation (control) of TLR9
2) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
Using these morphological criteria, TLR9 immunoreactivity was identified in mast cells (inset Figure 2E), dendritic cells (Figure 2E), granulocytes and lymphocytes (Figure 2E–F).
Regulation (immunoreactivity) of TLR9 in granulocytes
3) Confidence 0.27 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.26 Pain Relevance 0
TLR9 immunoreactivity was assessed and documented by bright field microscopy using an Olympus microscope (Olympus BX) coupled to a high resolution digital camera (Olympus D-50).


Regulation (immunoreactivity) of TLR9
4) Confidence 0.27 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.05 Pain Relevance 0.08
A distinct TLR9 immunoreactivity was also found in the endothelial cells lining small venules and capillaries (Figure 2D) and in subepithelial structural cells, tentatively identified as fibroblasts (Figure 2C).
Regulation (immunoreactivity) of TLR9 in fibroblasts
5) Confidence 0.24 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.35 Pain Relevance 0
Furthermore, since TLR9 is also involved in the pathogenesis of autoimmune mechanisms related to type 1 diabetes in experimental animals and TLR2 is involved in ?
Regulation (involved) of TLR9 associated with diabetes mellitus
6) Confidence 0.15 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 1.40 Pain Relevance 0.04
We have previously studied the effects of TLR9 ligands, i.e., CpG-A and CpG-B, on the induction of protein-specific immune responses in nonhuman primates.
Regulation (effects) of TLR9
7) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.57 Pain Relevance 0
Using these morphological criteria, TLR9 immunoreactivity was identified in mast cells (inset Figure 2E), dendritic cells (Figure 2E), granulocytes and lymphocytes (Figure 2E–F).
Regulation (immunoreactivity) of TLR9 in lymphocytes
8) Confidence 0.09 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.26 Pain Relevance 0

General Comments

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