INT204529

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 23
Disease Relevance 15.62
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR9) signal transduction (TLR9) extracellular region (TLR9)
endoplasmic reticulum (TLR9) plasma membrane (TLR9) intracellular (TLR9)
Anatomy Link Frequency
monocytes 3
alveolar macrophages 3
Plasmacytoid dendritic cells 2
lymphocytes 1
reservoir 1
TLR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 34 100.00 Very High Very High Very High
Multiple sclerosis 122 98.70 Very High Very High Very High
metalloproteinase 2 98.02 Very High Very High Very High
antagonist 17 94.48 High High
Inflammation 252 91.92 High High
psoriasis 45 89.36 High High
Central nervous system 69 87.64 High High
cytokine 265 80.88 Quite High
Inflammatory response 15 70.16 Quite High
cryotherapy 2 68.64 Quite High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 137 99.62 Very High Very High Very High
Cold Sores 367 99.52 Very High Very High Very High
Skin Cancer 74 99.46 Very High Very High Very High
Recurrence 54 98.86 Very High Very High Very High
Conjunctivitis 9 98.72 Very High Very High Very High
Demyelinating Disease 131 98.70 Very High Very High Very High
Systemic Lupus Erythematosus 13 98.00 Very High Very High Very High
Infection 263 94.20 High High
Autoimmune Disease 10 93.32 High High
INFLAMMATION 256 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M.tb DNA, in contrast, upregulated TLR9 mRNA in monocytes and alveolar macrophages after 24 h only (Figure 5C).
Positive_regulation (upregulated) of TLR9 mRNA in monocytes associated with mycobacterial infection
1) Confidence 0.62 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.47 Pain Relevance 0.12
Human tonsil B cells express high amounts of TLR9 mRNA and protein as determined by Western blot [35], which together with a low surface staining indicate a predominantly intracellular expression of TLR9 in lymphocytes.
Positive_regulation (amounts) of TLR9 in lymphocytes
2) Confidence 0.50 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.06 Pain Relevance 0.03
In another study, expression of TLR4 was upregulated and TLR9 downregulated in subjects with vernal keratoconjunctivitis compared to healthy controls [19].
Positive_regulation (upregulated) of TLR9 associated with conjunctivitis
3) Confidence 0.47 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.40 Pain Relevance 0.08
The increased expression of TLR9 in nasal lavage fluid indicates either that neutrophils expressing high levels of TLR9 are preferentially recruited to the nose (via the bloodstream from the bone marrow reservoir), or that neutrophils are primed with an increased expression of TLR9 as they migrate towards the nasal lumen.
Positive_regulation (levels) of TLR9 in reservoir
4) Confidence 0.47 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.24 Pain Relevance 0.05
These cells express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.
Positive_regulation (level) of TLR-9
5) Confidence 0.46 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 0.98 Pain Relevance 0.43
These cells express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.
Positive_regulation (level) of Toll-like receptor 9
6) Confidence 0.46 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 0.98 Pain Relevance 0.43
TLR9 mRNA was upregulated after 24 hours of incubation with M.tb DNA in both monocytes and alveolar macrophages in five of five study subjects indicating a slower kinetic of TLR9 mRNA generation than in the case of TLR2 and TLR4.
Positive_regulation (upregulated) of TLR9 mRNA in alveolar macrophages associated with mycobacterial infection
7) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.18 Pain Relevance 0.11
Alveolar macrophages expressed lower levels of TLR2, comparable levels of TLR4, and higher levels of TLR9 than monocytes.
Positive_regulation (levels) of TLR9 in Alveolar macrophages
8) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.45 Pain Relevance 0
Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS).
Positive_regulation (Activated) of TLR-9 associated with multiple sclerosis
9) Confidence 0.31 Published 2011 Journal J Neuroinflammation Section Abstract Doc Link PMC3022734 Disease Relevance 0.90 Pain Relevance 0.24
Activated via TLR-9, pDCs secrete large amounts of type I interferon [4].
Positive_regulation (Activated) of TLR-9
10) Confidence 0.31 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.04 Pain Relevance 0.43
Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse

The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.

Positive_regulation (level) of Toll-like receptor 9 in Plasmacytoid dendritic cells associated with multiple sclerosis and recurrence
11) Confidence 0.31 Published 2011 Journal J Neuroinflammation Section Title Doc Link PMC3022734 Disease Relevance 1.03 Pain Relevance 0.27
Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse

The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.

Positive_regulation (level) of TLR-9 in Plasmacytoid dendritic cells associated with multiple sclerosis and recurrence
12) Confidence 0.31 Published 2011 Journal J Neuroinflammation Section Title Doc Link PMC3022734 Disease Relevance 1.04 Pain Relevance 0.27
CYT003-QbG10, is a novel immunotherapy agent that consists of a virus-like particle, Qb and a short stretch of DNA from mycrobacteria that activates toll-like receptor 9 present in dendritic and other cells.
Positive_regulation (activates) of toll-like receptor 9
13) Confidence 0.22 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.29 Pain Relevance 0.05
SLE is associated with an increased production of Type I IFNs, most likely derived from pDCs following activation via TLR7 or TLR9.
Positive_regulation (activation) of TLR9 associated with systemic lupus erythematosus
14) Confidence 0.22 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.29 Pain Relevance 0.39
M.tb DNA, in contrast, upregulated TLR9 mRNA in monocytes and alveolar macrophages after 24 h only (Figure 5C).
Positive_regulation (upregulated) of TLR9 mRNA in alveolar macrophages associated with mycobacterial infection
15) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.47 Pain Relevance 0.12
The HSV TLR-dependent response entails TLR2, TLR3, TLR2/TLR6 heterodimer, TLR8 and TLR9.
Positive_regulation (entails) of TLR9 associated with cold sores
16) Confidence 0.19 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.39 Pain Relevance 0.16
TLR9 mRNA was upregulated after 24 hours of incubation with M.tb DNA in both monocytes and alveolar macrophages in five of five study subjects indicating a slower kinetic of TLR9 mRNA generation than in the case of TLR2 and TLR4.
Positive_regulation (upregulated) of TLR9 mRNA in monocytes associated with mycobacterial infection
17) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.18 Pain Relevance 0.11
A toll-like receptor 9 agonist, PF-3512676 (formerly known as CPG 7909) is currently being evaluated for its potential.


Positive_regulation (evaluated) of toll-like receptor 9 associated with agonist
18) Confidence 0.13 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2292185 Disease Relevance 0.66 Pain Relevance 0.05
Upon activation of TLR9, I?
Positive_regulation (activation) of TLR9
19) Confidence 0.11 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.39 Pain Relevance 0.08
This phagocytosis of haemozoin was reported i) to enhance matrix metalloproteinase-9 activity and TNF production in human monocytes [35,36], and ii) to reduce immune response by an activation of a Toll-like receptor 9 mediates mechanism [37].
Positive_regulation (activation) of Toll-like receptor 9 in monocytes associated with metalloproteinase
20) Confidence 0.10 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 0.49 Pain Relevance 0.09

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