INT204530

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.85
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR9) signal transduction (TLR9) extracellular region (TLR9)
endoplasmic reticulum (TLR9) plasma membrane (TLR9) intracellular (TLR9)
Anatomy Link Frequency
reservoir 6
lymphocytes 5
corneal epithelial cell 4
monocytes 2
bone marrow 2
TLR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 38 99.28 Very High Very High Very High
Inflammation 139 96.30 Very High Very High Very High
Central nervous system 16 80.84 Quite High
cytokine 129 76.52 Quite High
Bioavailability 32 73.92 Quite High
Inflammatory response 34 56.96 Quite High
alcohol 3 54.56 Quite High
tolerance 5 45.20 Quite Low
headache 4 24.12 Low Low
adenocard 3 9.20 Low Low
Disease Link Frequency Relevance Heat
Malaria 163 99.90 Very High Very High Very High
Demyelinating Disease 40 99.28 Very High Very High Very High
Granuloma 3 99.04 Very High Very High Very High
Infection 125 98.44 Very High Very High Very High
INFLAMMATION 175 96.30 Very High Very High Very High
Lung Cancer 3 93.00 High High
Critical Illness 37 92.80 High High
Cancer 4 91.44 High High
Hypersensitivity 128 90.16 High High
Disease 60 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of TLR9 in nasal lavage fluid indicates either that neutrophils expressing high levels of TLR9 are preferentially recruited to the nose (via the bloodstream from the bone marrow reservoir), or that neutrophils are primed with an increased expression of TLR9 as they migrate towards the nasal lumen.
Positive_regulation (increased) of Gene_expression (expression) of TLR9 in reservoir
1) Confidence 0.70 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.24 Pain Relevance 0.05
The increased expression of TLR9 in nasal lavage fluid indicates either that neutrophils expressing high levels of TLR9 are preferentially recruited to the nose (via the bloodstream from the bone marrow reservoir), or that neutrophils are primed with an increased expression of TLR9 as they migrate towards the nasal lumen.
Positive_regulation (increased) of Gene_expression (expression) of TLR9 in reservoir
2) Confidence 0.70 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.36 Pain Relevance 0.07
It is also possible that the bone marrow functions as a reservoir of granulocytes with an increased expression of TLR9, ready to be discharged in case of an infection.
Positive_regulation (increased) of Gene_expression (expression) of TLR9 in bone marrow associated with infection
3) Confidence 0.70 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.18 Pain Relevance 0.04
Human tonsil B cells express high amounts of TLR9 mRNA and protein as determined by Western blot [35], which together with a low surface staining indicate a predominantly intracellular expression of TLR9 in lymphocytes.
Positive_regulation (amounts) of Gene_expression (express) of TLR9 in lymphocytes
4) Confidence 0.50 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.06 Pain Relevance 0.03
The increased expression of TLR9 in nasal lavage fluid indicates either that neutrophils expressing high levels of TLR9 are preferentially recruited to the nose (via the bloodstream from the bone marrow reservoir), or that neutrophils are primed with an increased expression of TLR9 as they migrate towards the nasal lumen.
Positive_regulation (levels) of Gene_expression (expressing) of TLR9 in reservoir
5) Confidence 0.47 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.24 Pain Relevance 0.05
These cells express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.
Positive_regulation (level) of Gene_expression (express) of Toll-like receptor 9
6) Confidence 0.46 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 0.99 Pain Relevance 0.43
TLR9 transfected HEK293 cells expressed intracellular TLR9 only (as previously reported [27]).
Positive_regulation (transfected) of Gene_expression (transfected) of TLR9
7) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.32 Pain Relevance 0.03
Although all cultured limbal epithelial cell samples were positive for TLR9 expression, none of the corneal epithelial cell samples showed positive TLR9 expression.
Positive_regulation (positive) of Gene_expression (expression) of TLR9 in corneal epithelial cell
8) Confidence 0.42 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.06 Pain Relevance 0.07
Although all cultured limbal epithelial cell samples were positive for TLR9 expression, none of the corneal epithelial cell samples showed positive TLR9 expression.
Positive_regulation (positive) of Gene_expression (expression) of TLR9 in corneal epithelial cell
9) Confidence 0.42 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.05 Pain Relevance 0.06
TLR1, TLR2, and TLR4 expression was found on lymphocytes, myeloid cells and type II pneumocytes from granulomas of TB patients by immunocytochemistry, whereas TLR9 expression was restricted to macrophages and lymphocytes [23].
Positive_regulation (restricted) of Gene_expression (expression) of TLR9 in lymphocytes associated with granuloma
10) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.68 Pain Relevance 0.03
Tape stripping is used in various fields of cutaneous biology: for example, to evaluate the barrier function (34), to investigate dermatopathologies such as inflammatory or neoplastic disorders or xerotic conditions (35), to monitor gene expression (36,37), to investigate pH profiles (38), to evaluate animal skin as a surrogate for human skin (39), to induce Toll-like receptor 9 expression (40) and so on (41).
Positive_regulation (induce) of Gene_expression (expression) of Toll-like receptor 9 in skin associated with inflammation
11) Confidence 0.36 Published 2007 Journal Pharm Res Section Body Doc Link PMC2217624 Disease Relevance 0.16 Pain Relevance 0.14
These cells express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.
Positive_regulation (level) of Gene_expression (express) of TLR-9
12) Confidence 0.33 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 0.99 Pain Relevance 0.43
Adults with severe and mild malaria had increased expression of TLR2 and TLR4 on CD14+ monocytes and myeloid DCs and decreased expression of TLR9 on plasmacytoid DCs compared to adults with no history of malaria exposure (95).
Positive_regulation (increased) of Gene_expression (expression) of TLR9 in monocytes associated with malaria
13) Confidence 0.28 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 1.02 Pain Relevance 0
The expression of TLR3, TLR4, TLR7, TLR8 and TLR9 was significantly higher in mild cases than controls (p?
Positive_regulation (higher) of Gene_expression (expression) of TLR9
14) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.82 Pain Relevance 0.03
TLR1, TLR2, and TLR4 expression was found on lymphocytes, myeloid cells and type II pneumocytes from granulomas of TB patients by immunocytochemistry, whereas TLR9 expression was restricted to macrophages and lymphocytes [23].
Positive_regulation (restricted) of in macrophages Gene_expression (expression) of TLR9 in lymphocytes associated with granuloma
15) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox