INT204547

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.08
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a2) extracellular region (Col1a2) proteinaceous extracellular matrix (Col1a2)
protein binding, bridging (Col1a2)
Anatomy Link Frequency
CII 2
Col1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Acupuncture 57 98.32 Very High Very High Very High
Arthritis 48 97.92 Very High Very High Very High
Inflammation 14 90.68 High High
rheumatoid arthritis 19 77.04 Quite High
cytokine 9 68.32 Quite High
Pain 9 5.00 Very Low Very Low Very Low
backache 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 13 99.76 Very High Very High Very High
Arthritis 55 97.92 Very High Very High Very High
Autoimmune Disease 4 96.16 Very High Very High Very High
Sprains And Strains 2 92.72 High High
Intervertebral Disk Degeneration 31 90.76 High High
INFLAMMATION 13 90.68 High High
Rheumatoid Arthritis 19 77.04 Quite High
Disease Progression 1 73.52 Quite High
Disease 3 62.76 Quite High
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, preliminary studies investigating the use of Sox9 gene therapy support this idea: transduced cells from degenerate human discs showed enhanced collagen II production (Paul et al., 2003).
Positive_regulation (enhanced) of Gene_expression (production) of collagen II
1) Confidence 0.04 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.18 Pain Relevance 0
In the present study, CII immunization remarkably increased collagen II antibody, IgG and IgM levels in mice serum, while EA at ST36 significantly reduced these levels in comparison with the control group or the NR group.
Positive_regulation (increased) of Gene_expression (antibody) of collagen II in CII associated with immunization and acupuncture
2) Confidence 0.03 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.90 Pain Relevance 0.91

General Comments

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