INT20455

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 7.22
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bche) extracellular region (Bche) endoplasmic reticulum (Bche)
Anatomy Link Frequency
plasma 2
nerve 2
brain 2
Bche (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 100.00 Very High Very High Very High
anesthesia 11 99.64 Very High Very High Very High
Dismenorea 12 98.72 Very High Very High Very High
antidepressant 5 97.08 Very High Very High Very High
halothane 4 95.52 Very High Very High Very High
Analgesic 3 95.16 Very High Very High Very High
Antiemetics 1 94.52 High High
noradrenaline 8 94.32 High High
agonist 6 84.48 Quite High
cINOD 5 84.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 12 100.00 Very High Very High Very High
Anxiety Disorder 12 100.00 Very High Very High Very High
Obesity 100 99.68 Very High Very High Very High
Reprotox - General 1 11 98.72 Very High Very High Very High
Syndrome 15 98.68 Very High Very High Very High
Targeted Disruption 112 98.16 Very High Very High Very High
Blister 4 98.16 Very High Very High Very High
Disease 170 97.56 Very High Very High Very High
Poisoning 20 97.20 Very High Very High Very High
Parkinson's Disease 4 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: A trend of correlation was noted between preoperative serum pseudocholinesterase levels and visual assessment score: serum pseudocholinesterase levels increased as visual assessment score increased.
Positive_regulation (increased) of serum pseudocholinesterase
1) Confidence 0.59 Published 2000 Journal Spine Section Body Doc Link 10908934 Disease Relevance 0 Pain Relevance 0
Cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (AChE) while the role of butyrylcholinesterase (BChE) for brain cholinergic function is unclear.
Positive_regulation (role) of butyrylcholinesterase in brain
2) Confidence 0.49 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.38 Pain Relevance 0.11
Longer pulse trains, 120 pulses/3 Hz and 600 pulses/5 Hz, were used and the cholinesterase inhibitor physostigmine was added to the superfusion medium to increase synaptic levels of endogenous acetylcholine.
Positive_regulation (increase) of cholinesterase
3) Confidence 0.48 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15375642 Disease Relevance 0 Pain Relevance 0.42
We had previously shown that their butyrylcholinesterase activity was normal and had not increased.
Neg (not) Positive_regulation (increased) of butyrylcholinesterase
4) Confidence 0.46 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12667913 Disease Relevance 0.46 Pain Relevance 0.19
Considering the increased prevalence of reduced pseudocholinesterase activity in patients with HELLP syndrome, the authors suggest that whenever general anesthesia is applied in these patients, the anesthesiologist should be aware that the patient may show slow metabolic degradation of choline-ester drugs.
Positive_regulation (increased) of pseudocholinesterase associated with anesthesia and syndrome
5) Confidence 0.45 Published 2007 Journal Reprod Sci Section Abstract Doc Link 17636231 Disease Relevance 0.70 Pain Relevance 0.10
Cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (AChE) while the role of butyrylcholinesterase (BChE) for brain cholinergic function is unclear.
Positive_regulation (role) of BChE in brain
6) Confidence 0.43 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.38 Pain Relevance 0.11
Increased cholinesterase levels were observed in workers handling fluorine compounds in a plastics factory [10].
Positive_regulation (Increased) of cholinesterase
7) Confidence 0.30 Published 2002 Journal Crit Care Section Body Doc Link PMC137451 Disease Relevance 0.44 Pain Relevance 0.30
Pseudocholinesterase, a possible marker for trait anxiety, was found elevated in 6 of 14 (43%) of the severe PMS subjects, in 2 of the 14 (14%) moderate PMS subjects, and in none of the mild PMS subjects.
Positive_regulation (elevated) of Pseudocholinesterase associated with anxiety disorder and dismenorea
8) Confidence 0.27 Published 1985 Journal J Clin Psychiatry Section Abstract Doc Link 4038979 Disease Relevance 1.63 Pain Relevance 1.01
One way to achieve plasma stability and longer half-life of recombinant BChE while maintaining its biological activity is to provide a recombinantly produced BChE fused to human serum albumin (hSA).
Positive_regulation (provide) of BChE in plasma
9) Confidence 0.24 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.18 Pain Relevance 0.03
Of particular interest are the potential interactions of cholinesterase inhibitors with other drugs of current use in patients with AD, such as antidepressants, neuroleptics, antiarrhythmics, analgesics, and antiemetics which are metabolized by the cytochrome P450 CYP2D6 enzyme (Bernard et al 2006).
Positive_regulation (interactions) of cholinesterase associated with antidepressant, analgesic, disease and antiemetics
10) Confidence 0.18 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.54 Pain Relevance 0.19
Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning.
Positive_regulation (eliciting) of anti-cholinesterase in nerve associated with inflammation, blister and poisoning
11) Confidence 0.16 Published 2005 Journal Chem. Biol. Interact. Section Title Doc Link 16498717 Disease Relevance 0.84 Pain Relevance 0.44
Higher levels of pseudocholinesterase activity were generally associated with a higher mivacurium infusion requirement.
Positive_regulation (levels) of pseudocholinesterase
12) Confidence 0.16 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2141969 Disease Relevance 0 Pain Relevance 0.48
Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning.
Positive_regulation (eliciting) of anti-cholinesterase in nerve associated with inflammation, blister and poisoning
13) Confidence 0.13 Published 2006 Journal J Appl Toxicol Section Title Doc Link 16167317 Disease Relevance 0.85 Pain Relevance 0.29
The two blunt-ended fragments were ligated to generate bCN/BChE/hSA for pronuclear microinjection to produce transgenic mice.
Positive_regulation (generate) of BChE associated with targeted disruption
14) Confidence 0.10 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.42 Pain Relevance 0
Plasma cholinesterase activity is increased in the obese requiring an initial larger dose.
Positive_regulation (increased) of Plasma cholinesterase in Plasma associated with obesity
15) Confidence 0.01 Published 2010 Journal Indian Journal of Anaesthesia Section Body Doc Link PMC3016570 Disease Relevance 0.41 Pain Relevance 0.06

General Comments

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