INT20456

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Context Info
Confidence 0.41
First Reported 1983
Last Reported 1990
Negated 3
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.26
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pomc, Penk) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
blood 1
Pomc (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 22 100.00 Very High Very High Very High
Morphine 12 100.00 Very High Very High Very High
cva 2 99.90 Very High Very High Very High
antagonist 4 99.72 Very High Very High Very High
Dynorphin 5 98.68 Very High Very High Very High
Analgesic 1 95.88 Very High Very High Very High
agonist 2 95.00 High High
analgesia 3 89.04 High High
Opioid 3 75.12 Quite High
Endogenous opioid 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 3 98.16 Very High Very High Very High
Hypoxia 1 67.40 Quite High
Catalepsy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A portion of [3H]-beta-endorphin binding is sensitive to low concentrations of morphine or D-Ala2-Leu5-enkephalin (less than 5 nM).
beta-endorphin Binding (binding) of enkephalin associated with enkephalin and morphine
1) Confidence 0.41 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6092561 Disease Relevance 0 Pain Relevance 0.64
Treating membrane homogenates with naloxonazine, a mu1 selective antagonist, lowers [3H]-beta-endorphin binding to the same degree as morphine and D-Ala2-Leu5-enkephalin alone or together.
beta-endorphin Binding (binding) of enkephalin associated with antagonist, enkephalin and morphine
2) Confidence 0.35 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6092561 Disease Relevance 0 Pain Relevance 0.86
A portion of [3H]-beta-endorphin binding is sensitive to low concentrations of morphine or D-Ala2-Leu5-enkephalin (less than 5 nM).
beta-endorphin Binding (binding) of enkephalin associated with enkephalin and morphine
3) Confidence 0.30 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6092561 Disease Relevance 0 Pain Relevance 0.64
[The met-enkephalin and beta-endorphin content of the blood in the early period after acute blood loss in rats].
beta-endorphin Binding (content) of met-enkephalin in blood associated with pressure volume 2 under development, cva and enkephalin
4) Confidence 0.15 Published 1990 Journal Biull Eksp Biol Med Section Title Doc Link 2142006 Disease Relevance 0.26 Pain Relevance 0.62
Corticotropin-releasing factor: immunohistochemical colocalization with adrenocorticotropin and beta-endorphin, but not with Met-enkephalin, in subpopulations of duodenal perikarya of rat.
beta-endorphin Neg (not) Binding (colocalization) of Met-enkephalin associated with enkephalin
5) Confidence 0.10 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2985078 Disease Relevance 0 Pain Relevance 0.18
Corticotropin-releasing factor: immunohistochemical colocalization with adrenocorticotropin and beta-endorphin, but not with Met-enkephalin, in subpopulations of duodenal perikarya of rat.
adrenocorticotropin Neg (not) Binding (colocalization) of Met-enkephalin associated with enkephalin
6) Confidence 0.10 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2985078 Disease Relevance 0 Pain Relevance 0.18
However, this site was distinguished from kappa sites labelled with [3H]-ethylketazocine by its high affinity for Met5-enkephalin Arg6.Phe7 and beta-endorphin as well as its low affinity for dynorphin 1-13.
beta-endorphin Binding (affinity) of Met5-enkephalin associated with dynorphin and enkephalin
7) Confidence 0.06 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319874 Disease Relevance 0 Pain Relevance 0.34
The delta-selective ligand D-Pen2, D-pen5enkephalin was least effective at inhibiting the cross-linking of beta-endorphin, whereas the micro-selective ligand Tyr-D-Ala-Gly-NMe-Phe-Gly-ol and kappa-selective ligand U50488 inhibited beta-endorphin cross-linking to the 108,000 and 73,000 Da species.
beta-endorphin Neg (inhibiting) Binding (cross-linking) of D-pen5enkephalin
8) Confidence 0.01 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 2848185 Disease Relevance 0 Pain Relevance 0.23
The delta-selective ligand D-Pen2, D-pen5enkephalin was least effective at inhibiting the cross-linking of beta-endorphin, whereas the micro-selective ligand Tyr-D-Ala-Gly-NMe-Phe-Gly-ol and kappa-selective ligand U50488 inhibited beta-endorphin cross-linking to the 108,000 and 73,000 Da species.
beta-endorphin Binding (cross-linking) of D-pen5enkephalin
9) Confidence 0.01 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 2848185 Disease Relevance 0 Pain Relevance 0.23

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