INT20457

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2009
Negated 5
Speculated 6
Reported most in Abstract
Documents 23
Total Number 29
Disease Relevance 11.63
Pain Relevance 11.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
macrophages 2
liver 1
brain 1
fibroblast 1
stomach fundus 1
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 83 100.00 Very High Very High Very High
COX2 11 100.00 Very High Very High Very High
cOX1 5 100.00 Very High Very High Very High
tricyclic antidepressant 3 100.00 Very High Very High Very High
Inflammation 34 99.92 Very High Very High Very High
cytokine 13 99.76 Very High Very High Very High
depression 15 99.60 Very High Very High Very High
opiate 3 99.50 Very High Very High Very High
aspirin 52 99.48 Very High Very High Very High
nociceptor 1 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 58 100.00 Very High Very High Very High
Alzheimer's Dementia 13 100.00 Very High Very High Very High
Depression 24 99.60 Very High Very High Very High
Targeted Disruption 20 98.94 Very High Very High Very High
Cancer 84 98.76 Very High Very High Very High
Peptic Ulcer 3 98.64 Very High Very High Very High
Toxicity 6 98.08 Very High Very High Very High
Pancreatic Cancer 84 98.00 Very High Very High Very High
Influenza Virus Infection 6 97.76 Very High Very High Very High
Age-related Macular Degeneration 1 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SA was not expected to have any effect in this assay because it is known not to affect PGHS-1 or 2 activity [31] except in intact cells [30], possibly by suppressing PGHS-2 transcription in response to exogenous stimuli [32].
Neg (except) Spec (possibly) Regulation (affect) of PGHS-1
1) Confidence 0.48 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1592475 Disease Relevance 0 Pain Relevance 0.09
Estimation of the in vivo effect of cyclooxygenase inhibitors on prostaglandin E2 levels in mouse brain.
Regulation (effect) of cyclooxygenase in brain associated with aspirin
2) Confidence 0.45 Published 1990 Journal Eur. J. Pharmacol. Section Title Doc Link 2142085 Disease Relevance 0 Pain Relevance 0.42
We investigated the roles of cyclooxygenase (COX) isozymes and prostaglandin E (PGE) receptor EP1 and EP3 subtypes or prostacyclin IP receptors in the decrease in acid secretion in the damaged mouse stomach.
Spec (investigated) Regulation (roles) of cyclooxygenase in stomach
3) Confidence 0.44 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17928639 Disease Relevance 0 Pain Relevance 0.08
We examined the roles of cyclooxygenase (COX) isozymes, prostaglandins (PGs), and their receptors in the mucosal defense against ischemia/reperfusion (I/R)-induced gastric lesions in mice.
Spec (examined) Regulation (roles) of COX associated with ischemia
4) Confidence 0.44 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16236816 Disease Relevance 0.32 Pain Relevance 0.19
We examined the roles of cyclooxygenase (COX) isozymes, prostaglandins (PGs), and their receptors in the mucosal defense against ischemia/reperfusion (I/R)-induced gastric lesions in mice.
Spec (examined) Regulation (roles) of cyclooxygenase associated with ischemia
5) Confidence 0.44 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16236816 Disease Relevance 0.32 Pain Relevance 0.19
The discordant effects on beta amyloid and cyclooxygenase (COX) suggest that these effects of nonsteroidal anti-inflammatory drugs (NSAIDs) are not causally linked.
Regulation (effects) of cyclooxygenase associated with inflammation, alzheimer's dementia and cinod
6) Confidence 0.43 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12667645 Disease Relevance 1.14 Pain Relevance 0.36
The subtle modification of a selection of Abeta42 inhibiting non-steroidal anti-inflammatory drugs (NSAIDs), through synthesis of the geminal dimethyl analogues, was anticipated to ablate their cyclooxygenase activity whilst maintaining Abeta42 inhibition.
Regulation (ablate) of cyclooxygenase associated with inflammation and cinod
7) Confidence 0.39 Published 2006 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 16455248 Disease Relevance 0.17 Pain Relevance 0.29
The results show that the metabolism of arachidonic acid in macrophages via the cyclooxygenase or the lipoxygenase pathway is dependent on the stimulus applied.
Regulation (metabolism) of cyclooxygenase in macrophages
8) Confidence 0.39 Published 1985 Journal Int J Tissue React Section Abstract Doc Link 3928518 Disease Relevance 0.15 Pain Relevance 0.13
The results show that the metabolism of arachidonic acid in macrophages via the cyclooxygenase or the lipoxygenase pathway is dependent on the stimulus applied.
Regulation (metabolism) of cyclooxygenase in macrophages
9) Confidence 0.39 Published 1984 Journal Agents Actions Section Abstract Doc Link 6433678 Disease Relevance 0.22 Pain Relevance 0.32
Recent studies have demonstrated that cyclooxygenase (COX) pathway might modulate the neurotransmission of gamma-aminobutyric acid and dopamine in the central nervous system.
Spec (might) Regulation (modulate) of cyclooxygenase in central nervous system associated with dopamine and central nervous system
10) Confidence 0.38 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17049975 Disease Relevance 0 Pain Relevance 0.37
Thus, the data support the conclusion that APAP-induced hepatoxicity may be modulated not only by inhibition of cytochrome P450 mediated oxidation, but also by controlling hepatic cyclooxygenase activity.
Regulation (controlling) of hepatic cyclooxygenase associated with paracetamol
11) Confidence 0.27 Published 1990 Journal Arch. Toxicol. Section Abstract Doc Link 2386430 Disease Relevance 0.50 Pain Relevance 0.72
However, the cyclooxygenase inhibitor indomethacin did not affect contraction or relaxation to carbamylcholine in stomach fundus from wild-type or M(3) receptor knockout mice, indicating that cyclooxygenase products played no role in these responses.
Neg (not) Regulation (affect) of cyclooxygenase in stomach fundus associated with targeted disruption
12) Confidence 0.25 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538821 Disease Relevance 0.27 Pain Relevance 0.13
These results indicated that the analgesic effect of decursinol might be involved in supraspinal cyclooxygenase regulation that might be overlapped with APAP-induced analgesic mechanisms rather than systemic or peripheral prostaglandin modulation.
Regulation (regulation) of cyclooxygenase associated with paracetamol and analgesic
13) Confidence 0.24 Published 2009 Journal Arch. Pharm. Res. Section Abstract Doc Link 19557373 Disease Relevance 0.18 Pain Relevance 1.65
PGHS isozymes (-1 and -2) are the target for nonsteroidal anti-inflammatory drugs (NSAIDs).
Regulation (target) of PGHS associated with inflammation and cinod
14) Confidence 0.21 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1592475 Disease Relevance 0.29 Pain Relevance 0.29
Intracellular measurement of prostaglandin E2: effect of anti-inflammatory drugs on cyclooxygenase activity and prostanoid expression.
Regulation (effect) of cyclooxygenase associated with inflammation and cinod
15) Confidence 0.18 Published 1999 Journal Anal. Biochem. Section Title Doc Link 10361000 Disease Relevance 0.18 Pain Relevance 0.37
Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes.
Regulation (effect) of cyclooxygenase associated with withdrawal
16) Confidence 0.17 Published 2005 Journal Addict Biol Section Title Doc Link 16318954 Disease Relevance 0.08 Pain Relevance 0.35
Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice.
Regulation (Role) of cyclooxygenase associated with targeted disruption, peptic ulcer and cox1
17) Confidence 0.14 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 16373427 Disease Relevance 0.63 Pain Relevance 0.23
To investigate the mechanism of IFN-alpha-induced depression-like behavior, the effects of the tricyclic antidepressant imipramine, the cyclooxygenase inhibitor indomethacin, the opioid receptor antagonist naloxone, and the selective corticotropin-releasing hormone receptor antagonist CP-154, 526 on IFN-alpha-induced depression-like behavior were evaluated.
Regulation (effects) of cyclooxygenase associated with depression, antagonist, narcan, opioid receptor and tricyclic antidepressant
18) Confidence 0.11 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10604946 Disease Relevance 0.45 Pain Relevance 0.47
Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection.
Regulation (effects) of cyclooxygenase associated with influenza virus infection, viral infection and cox1
19) Confidence 0.11 Published 2005 Journal J. Immunol. Section Title Doc Link 16272346 Disease Relevance 1.02 Pain Relevance 0.59
The anti-inflammatory actions of the extract and the fraction may be due to an inhibitory effect on histamine and cyclooxygenase II, but not on cyclooxygenase I, because the extract and it's fraction present both anti-inflammatory and anti-ulcerogenic effects.
Neg (not) Regulation (effect) of cyclooxygenase I associated with inflammation
20) Confidence 0.10 Published 1998 Journal J Ethnopharmacol Section Abstract Doc Link 9705013 Disease Relevance 0.57 Pain Relevance 0.25

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