INT20462

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Context Info
Confidence 0.44
First Reported 1982
Last Reported 2010
Negated 9
Speculated 3
Reported most in Body
Documents 210
Total Number 213
Disease Relevance 102.70
Pain Relevance 26.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
MCF-7 3
epithelial cells 2
white blood cell 2
uterus 2
neurons 2
ESR1 (Homo sapiens)
ESR1 - G2014A (1)
Pain Link Frequency Relevance Heat
tramadol 361 100.00 Very High Very High Very High
cINOD 149 100.00 Very High Very High Very High
Paracetamol 56 100.00 Very High Very High Very High
aspirin 37 100.00 Very High Very High Very High
Migraine 7 100.00 Very High Very High Very High
backache 25 99.98 Very High Very High Very High
antagonist 208 99.96 Very High Very High Very High
agonist 1033 99.84 Very High Very High Very High
COX-2 inhibitor 46 99.78 Very High Very High Very High
Central nervous system 21 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 44 100.00 Very High Very High Very High
Low Back Pain 49 99.98 Very High Very High Very High
Disease 827 99.96 Very High Very High Very High
Stress 250 99.96 Very High Very High Very High
Apoptosis 1313 99.88 Very High Very High Very High
Obesity 1248 99.84 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 195 99.84 Very High Very High Very High
Breast Cancer 3850 99.76 Very High Very High Very High
Cancer 3660 99.70 Very High Very High Very High
Inflammatory Breast Neoplasms 385 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mimicking natural estrogens, they bind to estrogen receptor and modulate its activity.
estrogen receptor Binding (bind) of
1) Confidence 0.44 Published 2002 Journal Chem. Biol. Interact. Section Abstract Doc Link 11803026 Disease Relevance 0.41 Pain Relevance 0.08
The biological properties of the molecules were screened by (1) estrogen receptor (ER) binding, (2) effect on MCF-7 cells, (3) uterotrophic effect and inhibition of estradiol induced uterotropic effect and (4) antitumor effect in DMBA induced rat mammary cancer.
ER Binding (binding) of in MCF-7 associated with cancer
2) Confidence 0.41 Published 1990 Journal J. Steroid Biochem. Section Abstract Doc Link 2142231 Disease Relevance 0.09 Pain Relevance 0
There was no association between ESR and complications.
ESR Neg (no) Binding (association) of
3) Confidence 0.40 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC3004911 Disease Relevance 1.37 Pain Relevance 0.03
Given the evidence that the ER remains functional and can interact with growth factor signaling pathways, there is a strong rationale for combining novel signal transduction inhibitors with endocrine therapy rather than using them on their own.
ER Binding (interact) of
4) Confidence 0.37 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.39 Pain Relevance 0
This might explain the difference between our results and the association of ESR1 and male obesity previously reported [14].
ESR1 Binding (association) of associated with obesity
5) Confidence 0.37 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.91 Pain Relevance 0
ESR1 rs1801132, reported to be associated with BMI in men in the Framingham Heart Study [14], is according to the Caucasian HAPMAP data on the same haplotype as rs9397456, which was genotyped in this project.
ESR1 Binding (associated) of in Heart associated with obesity
6) Confidence 0.37 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.96 Pain Relevance 0
We have reported before that ESR1 rs2234693 and rs9340799 are not associated with obesity in a cohort of Swedish women partially overlapping with the cohort studied in this project [16].
ESR1 Binding (associated) of associated with obesity
7) Confidence 0.37 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.92 Pain Relevance 0
Relation of ESR1 SNPs and mRNA levels to adipocyte lipolysis and lipogenesis phenotypes
ESR1 Binding (Relation) of in adipocyte
8) Confidence 0.37 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.83 Pain Relevance 0.10
No ESR1 SNP displayed significant allelic association with obesity, but one SNP, rs2813544, was associated with obesity in analysis of homozygous subjects only, nominal P value 0.05, Table 4.
ESR1 Binding (association) of associated with obesity
9) Confidence 0.37 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.56 Pain Relevance 0
Association between ESR1 mRNA levels and lipolysis and lipogenesis measures was assessed by multiple regression with age and BMI as additional independent variables.
ESR1 Binding (Association) of associated with obesity
10) Confidence 0.37 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.39 Pain Relevance 0
Association between ESR1 mRNA levels and lipolytic responsiveness was stronger for the ?
ESR1 Binding (Association) of
11) Confidence 0.37 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.51 Pain Relevance 0.36
We did not genotype the three ESR1 SNP reported to be associated with BMI in African Americans [17]; however the reported BMI associated SNP rs6902771 is according to HAPMAP on the same haplotype as rs2234693, which we genotyped.
ESR1 Binding (associated) of associated with obesity
12) Confidence 0.37 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.16 Pain Relevance 0
Four hundred forty structurally unrelated compounds that can be found in human urine were shown not to cross-react with the Signify ER.
ER Binding (react) of in urine
13) Confidence 0.37 Published 2003 Journal Clin. Chim. Acta Section Abstract Doc Link 12559596 Disease Relevance 0 Pain Relevance 0.15
Fresh synovial tissue specimens were assessed for the localization as well as the presence of estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) by means of immunohistochemistry, as well as Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
estrogen receptor Binding (presence) of
14) Confidence 0.36 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
Fresh synovial tissue specimens were assessed for the localization as well as the presence of estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) by means of immunohistochemistry, as well as Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
ER alpha Binding (presence) of
15) Confidence 0.36 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
Fresh synovial tissue specimens were assessed for the localization as well as the presence of estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) by means of immunohistochemistry, as well as Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
estrogen receptor Binding (presence) of
16) Confidence 0.36 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
After 4 months under several antibiotic regimes his condition rapidly deteriorated with high fever, excruciating lumbar back pain associated with elevated ESR/WBC (ESR = erythrocyte sedimentation rate, WBC = white blood cell count) along with arthritis of the shoulders, wrists, knees and ankles.
ESR Binding (associated) of in white blood cell associated with fever, arthritis and backache
17) Confidence 0.36 Published 2010 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 20101555 Disease Relevance 1.15 Pain Relevance 0.54
After 4 months under several antibiotic regimes his condition rapidly deteriorated with high fever, excruciating lumbar back pain associated with elevated ESR/WBC (ESR = erythrocyte sedimentation rate, WBC = white blood cell count) along with arthritis of the shoulders, wrists, knees and ankles.
ESR Binding (associated) of in white blood cell associated with fever, arthritis and backache
18) Confidence 0.36 Published 2010 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 20101555 Disease Relevance 1.16 Pain Relevance 0.54
In this report we analyse ESR1 and ESR2 gene single nucleotide polymorphisms (SNPs) for association with obesity.
ESR1 Binding (association) of associated with obesity
19) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Abstract Doc Link PMC2238734 Disease Relevance 0.54 Pain Relevance 0
AS patients with osteoporosis showed significantly increased CRP, ESR, cross-links and PTH and a significantly decreased 1.25 D3.
ESR Binding (cross-links) of associated with spinal inflammation and osteoporosis
20) Confidence 0.35 Published 2005 Journal Osteoporos Int Section Abstract Doc Link 16172800 Disease Relevance 1.70 Pain Relevance 0.65

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