INT20470

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.76
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acsl1) endoplasmic reticulum (Acsl1) plasma membrane (Acsl1)
peroxisome (Acsl1) ligase activity (Acsl1) lipid metabolic process (Acsl1)
Anatomy Link Frequency
lumen 1
Acsl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1 99.68 Very High Very High Very High
Neurotransmitter 1 99.48 Very High Very High Very High
antagonist 2 97.64 Very High Very High Very High
intrathecal 1 96.58 Very High Very High Very High
Central nervous system 4 94.24 High High
Lasting pain 3 93.20 High High
Sciatic nerve 1 89.96 High High
fibrosis 15 87.32 High High
Spinal cord 3 85.68 High High
depression 111 85.16 High High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 44 100.00 Very High Very High Very High
Atherosclerotic Plaque 3 99.88 Very High Very High Very High
Rupture 5 96.64 Very High Very High Very High
Myocardial Infarction 48 93.64 High High
Systemic Sclerosis 77 93.28 High High
Pulmonary Hypertension 13 89.88 High High
Pulmonary Fibrosis 8 87.32 High High
Depression 123 85.16 High High
INFLAMMATION 18 83.08 Quite High
Heart Disease 24 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nearly 25% of ACAs occurred at induction and consisted mainly in TACAs.
Positive_regulation (induction) of ACAs
1) Confidence 0.40 Published 1990 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 2142588 Disease Relevance 0.76 Pain Relevance 0.07
Moreover, intrathecal injection of MK801, a noncompetitive NMDA antagonist, partially prevented these inductions, highlighting the involvement of the neurotransmitter glutamate in the central ACS and ACO up-regulation.
Positive_regulation (up-regulation) of ACS associated with glutamate, neurotransmitter, antagonist and intrathecal
2) Confidence 0.26 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622223 Disease Relevance 0.22 Pain Relevance 0.63
Since, all ACs mRNA examined here are increased during pregnancy, AC6 may be affected by other factor(s) other than estrogen and P4.
Positive_regulation (increased) of ACs
3) Confidence 0.18 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 15966510 Disease Relevance 0 Pain Relevance 0.06
Indeed, it is now recognized that the great majority of coronary atherosclerotic plaques that lead to ACS are typically relatively nonobstructive prior to the ACS, with a predisposition to rupture that is determined more by their intrinsic biology, than degree of protrusion into the coronary lumen.17
Positive_regulation (lead) of ACS in lumen associated with acute coronary syndrome, atherosclerotic plaque and rupture
4) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874336 Disease Relevance 2.02 Pain Relevance 0.15
However, these patients had similar characteristics than the limited subtype and not a specific antibody profile i.e. a preponderance of ACAs.
Positive_regulation (preponderance) of ACAs
5) Confidence 0.02 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468885 Disease Relevance 0.76 Pain Relevance 0.11

General Comments

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