INT204720

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD53) plasma membrane (CD53)
Anatomy Link Frequency
bone marrow 1
skin 1
corneal epithelium 1
CD53 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 53 99.84 Very High Very High Very High
psoriasis 44 33.28 Quite Low
chemokine 17 30.92 Quite Low
palliative 2 25.72 Quite Low
ischemia 1 18.48 Low Low
rheumatoid arthritis 88 16.60 Low Low
corticosteroid 2 9.64 Low Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
Inflammation 45 5.00 Very Low Very Low Very Low
Arthritis 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 34 100.00 Very High Very High Very High
Hypersensitivity 1 87.68 High High
Adhesions 3 76.72 Quite High
Disorders Of The Lacrimal System 1 76.60 Quite High
Diffuse Scleroderma 1 68.00 Quite High
Dry Eye 24 67.04 Quite High
Limited Scleroderma 1 63.76 Quite High
Increased Venous Pressure Under Development 6 63.44 Quite High
Autoimmune Disease 33 50.00 Quite Low
Disease 72 47.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among differentially expressed genes between SSc and normal control skin were calreticulin (CALR), collagens type V (COL5A2) and type XV (COL15A1), nidogen 2 (NID2), CD14, CD31, VE-cadherin, S100A7, and CD53.
Gene_expression (expressed) of CD53 in skin associated with systemic sclerosis
1) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.18 Pain Relevance 0.10
The healthy corneal epithelium is wettable by itself because of its ability to produce and maintain the transmembrane glycoprotein layer (MUC1).
Gene_expression (produce) of transmembrane glycoprotein in corneal epithelium
2) Confidence 0.01 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1859988 Disease Relevance 0.14 Pain Relevance 0
Another interesting finding was that AM-hMSCs expressed CD34 and showed increased expression of FLT-1 and KDR when cultured in the presence of VEGF: such expression, which recapitulates the basic phenotypic profile of circulating Endothelial Progenitor Cells (EPCs), is further evidence that AM-hMSCs have an angiogenic potential; the fact that, under the same culture conditions, AM-hMSCs did not express the CD133 surface molecule helps to distinguish these cells from the bone marrow-derived progenitors [41] (data not shown).
Neg (not) Gene_expression (express) of CD133 surface in bone marrow
3) Confidence 0.01 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0.06 Pain Relevance 0

General Comments

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