INT204763

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.22
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8)
cytoskeleton (S100a8) cytoplasm (S100a8)
Anatomy Link Frequency
joint 1
macrophages 1
phagocytes 1
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 310 100.00 Very High Very High Very High
cytokine 125 100.00 Very High Very High Very High
Arthritis 111 96.32 Very High Very High Very High
Inflammatory mediators 15 92.16 High High
Inflammatory response 23 89.48 High High
tolerance 10 73.52 Quite High
withdrawal 3 64.04 Quite High
rheumatoid arthritis 61 50.00 Quite Low
chemokine 21 46.76 Quite Low
cINOD 3 46.40 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 342 100.00 Very High Very High Very High
Necrosis 9 99.70 Very High Very High Very High
Targeted Disruption 51 99.58 Very High Very High Very High
Cancer 12 99.52 Very High Very High Very High
Inflammatory Bowel Disease 17 98.76 Very High Very High Very High
Obesity 33 96.64 Very High Very High Very High
Arthritis 118 96.32 Very High Very High Very High
Colitis 38 95.48 Very High Very High Very High
Stress 7 93.76 High High
Diabetes Mellitus 30 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To block the activity of S100A8 during CorNV development, 20 ?
Transcription (activity) of S100A8
1) Confidence 0.69 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0 Pain Relevance 0
S100A8 is almost not detectable at the protein level in mature phagocytes of S100A9 KO mice despite normal S100A8 mRNA levels, probably due to the elevated metabolism of S100A8 in the absence of its binding partner.
Transcription (levels) of S100A8 in phagocytes associated with targeted disruption
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.05 Pain Relevance 0.19
B mediates the transcription of pro-inflammatory cytokine genes.
Transcription (transcription) of pro-inflammatory associated with inflammation and cytokine
3) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.10 Pain Relevance 0.10
Next, we asked whether phagocytosis is associated with down-regulation of inflammatory cytokine gene transcription.
Transcription (transcription) of inflammatory cytokine gene associated with inflammation and cytokine
4) Confidence 0.05 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.54 Pain Relevance 0.18
The mRNA levels of the pro-inflammatory cytokines, TNF-?
Transcription (levels) of pro-inflammatory associated with inflammation and cytokine
5) Confidence 0.04 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.88 Pain Relevance 0.28
Therefore the enhancement of transcription of pro-inflammatory cytokine genes has been reported in this model [35].
Transcription (transcription) of pro-inflammatory associated with inflammation and cytokine
6) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.14 Pain Relevance 0.22
Following LPS stimulation, apoE4-macrophages showed higher and lower concentrations of tumour necrosis factor alpha (pro-inflammatory) and interleukin 10 (anti-inflammatory), respectively, both at mRNA and protein levels.
Transcription (mRNA) of pro-inflammatory in macrophages associated with necrosis, inflammation and cancer
7) Confidence 0.01 Published 2007 Journal Biochemical and Biophysical Research Communications Section Abstract Doc Link PMC2096715 Disease Relevance 1.01 Pain Relevance 0.23
Delivery of a rat TNF receptor:Fc fusion protein in a streptococcal cell wall-induced arthritis model by either plasmid or local or systemic administration of AAV vectors encoding the molecule led to decreased inflammation, pannus formation, bone and joint destruction, and mRNA expression of joint pro-inflammatory cytokines [21].
Transcription (expression) of pro-inflammatory in joint associated with inflammation, cytokine and arthritis
8) Confidence 0.00 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.49 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox