INT204766

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.14
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nod2) signal transduction (Nod2) plasma membrane (Nod2)
intracellular (Nod2) enzyme binding (Nod2) cytoplasm (Nod2)
Anatomy Link Frequency
ileum 1
DCs 1
Nod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 152 99.52 Very High Very High Very High
Inflammation 164 94.00 High High
tolerance 5 73.20 Quite High
cytokine 25 61.12 Quite High
spastic colon 3 37.28 Quite Low
Bile 18 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 208 100.00 Very High Very High Very High
Disease 192 99.52 Very High Very High Very High
INFLAMMATION 151 94.00 High High
Colitis 70 87.68 High High
Ileitis 3 81.84 Quite High
Pouchitis 3 79.92 Quite High
Sprains And Strains 42 79.24 Quite High
Metaplasia 9 68.48 Quite High
Infection 35 60.48 Quite High
Targeted Disruption 19 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we assume that the expression of IL-4 in IBD may not be a consistent pattern.
Gene_expression (expression) of IBD associated with inflammatory bowel disease
1) Confidence 0.75 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840610 Disease Relevance 0.97 Pain Relevance 0.25
Both gene products of NOD2 and NLRP3 play central roles in intracellular bacterial sensing and the CD associated variants of both genes were reported to result in a loss-of-function phenotype characterized by a decrease in secretion of IL-1?
Gene_expression (products) of NOD2 associated with crohn's disease
2) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.18 Pain Relevance 0.34
Corroborating the concept of a host driven composition of the microbial flora, Petnicki-Ocweija et al. showed that in the mouse model, the bactericidal activity of crypt secretions of the terminal ileum was severely compromised by NOD2 deletion, and that NOD2 expression depends on the presence of commensal bacteria [50].
Gene_expression (expression) of NOD2 in ileum
3) Confidence 0.51 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.13 Pain Relevance 0.04
Furthermore, the association between NOD2 mutation (L1007fsinsC) and particularly low ?
Gene_expression (mutation) of NOD2
4) Confidence 0.44 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.64 Pain Relevance 0.17
The preventive effect of probiotic-pulsed DCs required not only MyD88-, TLR2- and NOD2-dependent signaling but also the induction of CD4+ CD25+ regulatory cells in an IL-10-independent pathway.


Gene_expression (induction) of NOD2 in DCs
5) Confidence 0.43 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1819555 Disease Relevance 0.62 Pain Relevance 0.26
Further investigations revealed that 1,25-dihydroxyvitamin D3 and MDP induce expression of hBD-2 and cathelicidin through stimulation of NOD2 expression [88].
Gene_expression (expression) of NOD2
6) Confidence 0.40 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.60 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox