INT204775

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 13.60
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
macrophages 2
T cells 2
B cells 1
lungs 1
M1 macrophages 1
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 83 99.52 Very High Very High Very High
cytokine 260 99.20 Very High Very High Very High
fibrosis 18 99.20 Very High Very High Very High
tolerance 142 97.16 Very High Very High Very High
Inflammation 292 95.44 Very High Very High Very High
Inflammatory response 42 94.52 High High
ischemia 12 81.60 Quite High
Crohn's disease 1 57.92 Quite High
addiction 2 56.72 Quite High
metalloproteinase 4 47.16 Quite Low
Disease Link Frequency Relevance Heat
Cancer 979 99.68 Very High Very High Very High
Colitis 38 99.66 Very High Very High Very High
Pulmonary Fibrosis 12 99.60 Very High Very High Very High
Metastasis 554 99.56 Very High Very High Very High
Skin Cancer 96 99.08 Very High Very High Very High
Sprains And Strains 41 98.64 Very High Very High Very High
Immunotherapy Of Cancer 24 98.52 Very High Very High Very High
Experimental Melanoma 60 98.00 Very High Very High Very High
Death 99 97.04 Very High Very High Very High
Yersinia Infection 12 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, the TLR2/TLR6 heterodimer is involved in phosphorylation or nuclear translocation of Stat3 induced by macrophage activating lipopeptide-2 or LcrV of Yersinia pestis [28], [29].
Regulation (involved) of TLR2 in macrophage associated with yersinia infection
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.74 Pain Relevance 0.04
Changes in TLR2 and TLR4 levels in response to HSP70
Regulation (Changes) of TLR2
2) Confidence 0.38 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.09 Pain Relevance 0
TLR4 signalling up-regulates TLR2 in LPS (lipopolysaccharide)-stimulated macrophages, suggesting that the cross-talk between TLR2 and TLR4 works as a positive feedback loop [29].
Regulation (regulates) of TLR2 in macrophages
3) Confidence 0.33 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.23 Pain Relevance 0.04
Our studies not only demonstrate that targeting TLR2 generates metastases clearing immunity, but also reveals a signal transduction pathway in the tumor by which HSP60 liberated from B16 cells, causes a persistent activation of TLR2 to maintain the constitutive activity and function of Stat3 in these cells and determine the development of tumor immune tolerance.
Regulation (targeting) of TLR2 associated with cancer, tolerance and metastasis
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.01 Pain Relevance 0.04
The targeted sequences for the RNAi of mouse TLR2, TLR6, Dectin-1, and control were GGAACAGAGTGGCAACAGT, AGGAACCTTACTCATGTCC, GACAGCTTCCT ATCAAGAA, and GCGAGTAGCGCTAGGAAGT, respectively.
Regulation (control) of TLR2
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0 Pain Relevance 0
Our work indicates that targeting TLR2 not only enhances the tumoricidal CD8+ T cells, but also significantly eliminates the immunosuppressive cells and factors in tumor sites to enhance the efficacy of anti-tumor immunity [33].
Regulation (targeting) of TLR2 in T cells associated with cancer
6) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.94 Pain Relevance 0
Moreover, targeting TLR2 in the host or in the melanoma cells markedly inhibited the B16 cell-induced phosphorylation of Stat3 (Fig. 3F).
Regulation (targeting) of TLR2 associated with skin cancer
7) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.61 Pain Relevance 0.03
In contrast to the protective role of targeting TLR2 in the attenuation of tumor metastasis, targeting TLR4 aggravates the progress of melanoma metastasis associated with an enhancement of Stat3 activity and an increase of the tumor-infiltrating Tregs.
Regulation (targeting) of TLR2 associated with cancer, skin cancer and metastasis
8) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.47 Pain Relevance 0.14
Cells were grown in Petri dishes and arrested in medium containing 0.4% serum 6 hours before transfection with 0.2 ┬Ámol/L shRNA targeting TLR2, TLR6 or Dectin-1.
Regulation (targeting) of TLR2
9) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0 Pain Relevance 0
To investigate the regulatory effects of targeting TLR2 and TLR4 on the B16 cell-induced immune microenvironment, we examined the level of cytokines, such as IFN-?
Spec (investigate) Regulation (targeting) of TLR2 associated with cytokine
10) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.39 Pain Relevance 0.05
Moreover, targeting TLR2 markedly reduced pulmonary metastases and increased the survival of B16-bearing mice by reversing B16 cells induced immunosuppressive microenvironment and restoring tumor-killing cells such as CD8+ T cells and M1 macrophages.
Regulation (targeting) of TLR2 in M1 macrophages associated with cancer and metastasis
11) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2716531 Disease Relevance 1.26 Pain Relevance 0.13
Indeed, we recently find that targeting TLR2 reverses pulmonary fibrosis through regulating immunosuppressive microenvironment [14].
Regulation (targeting) of TLR2 associated with fibrosis and pulmonary fibrosis
12) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.29 Pain Relevance 0.21
Although up-regulation of TLR-2 by mechanical ventilation has been reported previously data on the effect of PAM3 on ventilated lungs are sparse [18].
Regulation (regulation) of TLR-2 in lungs
13) Confidence 0.24 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.56 Pain Relevance 0.35
In B cells, the TLR-like molecule radioprotective 105 (RP105) forms a complex with the MD-2 homolog MD-1 and is essential for regulating TLR2 and 4-dependent antibody production to the ligands lipoproteins and LPS.
Regulation (regulating) of TLR2 in B cells
14) Confidence 0.23 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.09 Pain Relevance 0.05
The fold changes in TLR2 and TLR4 levels with HSP70 stimulation were higher in patients with AMI (both local and systemic samples) compared with patients with SA and controls (Figure 4).
Regulation (changes) of TLR2
15) Confidence 0.23 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.08 Pain Relevance 0
Targeting TLR2 significantly attenuated pulmonary metastases of B16 melanoma and animal death.
Regulation (Targeting) of TLR2 associated with experimental melanoma, death and metastasis
16) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.43 Pain Relevance 0.21
Kinases and scaffolding proteins downstream of TLR2 and TLR4 were involved in the enhancement of NF-?
Regulation (involved) of TLR2
17) Confidence 0.18 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.02 Pain Relevance 0.30
We provide evidence that reduced SOCS activity licenses greater cytokine production through diminished negative regulation of the TLR2 pathway.
Regulation (regulation) of TLR2 associated with cytokine
18) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.41 Pain Relevance 0.35
p38-STAT1-IRF1 signaling positively regulates socs activity [26],[30] and negatively regulates tlr2 activity [37].
Regulation (ely regul) of tlr2
19) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0.03
The administration of deficient BMDCs conditioned by the probiotic strain, did not affect the course and severity of colitis, indicating the involvement of both the TLR2 and NOD2 signaling pathways in the control of the colitis.
Regulation (involvement) of TLR2 associated with colitis and sprains and strains
20) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.66 Pain Relevance 0.07

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