INT204781

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.79
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nod2) signal transduction (Nod2) plasma membrane (Nod2)
intracellular (Nod2) enzyme binding (Nod2) cytoplasm (Nod2)
Anatomy Link Frequency
plasma 1
epithelial cells 1
CMT-93 1
Nod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 23 93.68 High High
cytokine 21 83.92 Quite High
Inflammation 170 73.04 Quite High
potassium channel 1 50.24 Quite High
isoflurane 3 27.52 Quite Low
Bile 12 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 127 96.92 Very High Very High Very High
Targeted Disruption 13 96.46 Very High Very High Very High
Disease 57 93.68 High High
Inflammatory Bowel Disease 49 89.56 High High
Bacterial Respiratory Disease 11 87.88 High High
Colitis 97 85.28 High High
Bacterial Meningitis 3 78.12 Quite High
Mycobacterial Infection 4 76.96 Quite High
INFLAMMATION 165 73.04 Quite High
Congenital Anomalies 1 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently Watanabe and colleagues proposed that peptidoglycan (PGN)-mediated activation of TLR2 signaling is negatively regulated by MDP-mediated activation of NOD2 signaling [42].
Positive_regulation (activation) of NOD2
1) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.66 Pain Relevance 0.11
B signaling on C. jejuni-induced endogenous gene expression, we next measured IL-6, MIP-2 and NOD2 mRNA accumulation in cells expressing the I?
Positive_regulation (accumulation) of NOD2
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760752 Disease Relevance 0.08 Pain Relevance 0
Moreover, Cadwell et al. provided evidence that in ATG16L1 knockout mice, granule exocytosis is abnormal [67, 68], and recently it has been shown that recruitment of ATG16L1 to the site of bacterial entry in the plasma membrane is dependent on activation of NOD2 by bacteria ([69]).
Positive_regulation (activation) of NOD2 in plasma associated with targeted disruption
3) Confidence 0.31 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.74 Pain Relevance 0.21
Interestingly, we observed a strong induction of NOD2 mRNA in C. jejuni infected CMT-93 cells suggesting a potential role for this innate sensor in controlling infection.
Positive_regulation (induction) of NOD2 in CMT-93 associated with infection
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760752 Disease Relevance 0.60 Pain Relevance 0
and NOD2 mRNA accumulation in infected-mouse colonic epithelial cells CMT93.
Positive_regulation (accumulation) of NOD2 in epithelial cells
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2760752 Disease Relevance 0.29 Pain Relevance 0.08
The nucleotide-binding oligomerization domain 2 (NOD2) is activated by muramyl dipeptide (MDP), which is another degradation product of the peptidoglycan produced by lysozyme and other (bacterial) peptidoglycan hydrolases.
Positive_regulation (activated) of nucleotide-binding oligomerization domain 2
6) Confidence 0.06 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.42 Pain Relevance 0.06

General Comments

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