INT204783

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 17
Total Number 21
Disease Relevance 15.53
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il23a) extracellular region (Il23a)
Anatomy Link Frequency
dendritic cells 6
fibroblasts 5
microglia 4
smooth muscle 2
monocytes 2
Il23a (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 119 100.00 Very High Very High Very High
Inflammation 443 99.84 Very High Very High Very High
Inflammatory mediators 20 99.16 Very High Very High Very High
agonist 87 98.70 Very High Very High Very High
Crohn's disease 237 98.12 Very High Very High Very High
cytokine 571 95.20 Very High Very High Very High
Arthritis 59 94.32 High High
adenocard 3 85.84 High High
cINOD 22 83.92 Quite High
Central nervous system 29 81.68 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 119 100.00 Very High Very High Very High
Rhinitis 3 99.96 Very High Very High Very High
INFLAMMATION 472 99.84 Very High Very High Very High
Multiple Sclerosis 56 99.32 Very High Very High Very High
Sprains And Strains 119 98.30 Very High Very High Very High
Disease 532 98.12 Very High Very High Very High
Cancer 335 97.68 Very High Very High Very High
Asthma 105 97.32 Very High Very High Very High
Paralysis 2 97.16 Very High Very High Very High
Inflammatory Bowel Disease 247 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Positive_regulation (triggers) of Gene_expression (expression) of IL-23A in fibroblasts
1) Confidence 0.36 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.63 Pain Relevance 0.26
Adoptive transfer of either IL-12p70– or IL-23–polarized T cells into naive syngeneic hosts resulted in an ascending paralysis that was clinically indistinguishable between the two groups.
Positive_regulation (transfer) of Gene_expression (transfer) of IL-23 in T cells associated with paralysis
2) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442630 Disease Relevance 0.42 Pain Relevance 0.23
In experimental autoimmune encephalomyelitis (EAE), it was reported that there was enhanced IL-12/IL-23 p40 expression in p55?
Positive_regulation (enhanced) of Gene_expression (expression) of IL-23 p40 associated with multiple sclerosis
3) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 1.18 Pain Relevance 0.32
Main evidence includes demonstration of the presence of Th17 cells in lungs of mice intranasally infected with LVS [30], and that in vitro exposure of human peripheral blood monocytes to F. novicida induce the production of IL-23 [31].
Positive_regulation (induce) of Gene_expression (production) of IL-23 in monocytes associated with sprains and strains
4) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.01 Pain Relevance 0.30
Following studies were conducted at each time point: histological changes of jejunum were observed; the jejunal smooth muscle contractility was investigated in response to acetylcholine; the levels of IL-17, IL-23, and TGF-?
Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Gene_expression (levels) of IL-23 in smooth muscle
5) Confidence 0.21 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2786920 Disease Relevance 0.22 Pain Relevance 0
We could show increased mRNA expression levels of both IL-23 and IL-17 upon TNBS treatment, which were greatly reduced by Lr32-pulsed DCs.
Positive_regulation (increased) of Gene_expression (expression) of IL-23
6) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.08 Pain Relevance 0.29
42 synergistically elevated the expression of IL-12 and IL-23 triggered by inflammatory activation of microglia, and the peroxisome proliferator-activated receptor (PPAR)-?
Positive_regulation (elevated) of Gene_expression (expression) of IL-23 in microglia associated with inflammation
7) Confidence 0.14 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2442897 Disease Relevance 1.05 Pain Relevance 0.26
42 synergistically elevated the expression of IL-12 and IL-23 triggered by inflammatory activation of microglia, and the peroxisome proliferator-activated receptor (PPAR)-?
Positive_regulation (triggered) of Gene_expression (expression) of IL-23 in microglia associated with inflammation
8) Confidence 0.14 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2442897 Disease Relevance 1.04 Pain Relevance 0.26
produce high levels of IL-12 and IL-23 [18] combined with low levels of IL-10
Positive_regulation (levels) of Gene_expression (produce) of IL-23
9) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.66 Pain Relevance 0.22
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Positive_regulation (triggers) of in endothelial cells Gene_expression (expression) of IL-23A in fibroblasts
10) Confidence 0.12 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.63 Pain Relevance 0.26
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Positive_regulation (triggers) of in epithelial cells Gene_expression (expression) of IL-23A in fibroblasts
11) Confidence 0.12 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.63 Pain Relevance 0.26
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Positive_regulation (triggers) of in macrophages Gene_expression (expression) of IL-23A in fibroblasts
12) Confidence 0.12 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.63 Pain Relevance 0.26
TAMs with the M1 phenotype are characterized by a high capacity to present antigen, high IL-12 and IL-23 production, and high production of toxic intermediates, such as nitric oxide and reactive oxygen intermediates.
Positive_regulation (high) of Gene_expression (production) of IL-23
13) Confidence 0.12 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 1.00 Pain Relevance 0
TAMs with the M1 phenotype are characterized by a high capacity to present antigen, high IL-12 and IL-23 production, and high production of toxic intermediates, such as nitric oxide and reactive oxygen intermediates.
Positive_regulation (present) of Gene_expression (production) of IL-23
14) Confidence 0.12 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 1.06 Pain Relevance 0
Finally, treatment of E. coli-activated dendritic cells with forskolin, an agent that activates adenylate cyclase independently of GPCR activation, also inhibits IL-12 (protein) output while enhancing IL-23p19 (message) expression [65].
Positive_regulation (enhancing) of Gene_expression (expression) of IL-23p19 in dendritic cells
15) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.08
On this basis, it was concluded that the P2Y11 receptor is responsible for the nucleotide-mediated antagonism of IL-12 production whereas a separate, ADP-sensitive P2 receptor subtype is responsible for promoting IL-23 production [65].Sorting out the identity of P2 receptors that mediate the aforementioned effects of nucleotides on dendritic cell cytokine output is complicated by the existence of cell surface nucleotidases such as CD39 [37].
Positive_regulation (promoting) of Gene_expression (production) of IL-23 in dendritic cell associated with cytokine
16) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.08
This hypothesis was supported by an in vivo study showing that airway infiltrating TH17 cells together with local IL-23 expression significantly enhanced eosinophilic airway inflammation in a mouse model of experimental asthma [113].
Positive_regulation (enhanced) of Gene_expression (expression) of IL-23 associated with asthma, rhinitis and inflammation
17) Confidence 0.09 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.81 Pain Relevance 0.05
If these findings were transferable to human RA, IL-23 would have a pro-inflammatory role and IL-12 a protective one.
Positive_regulation (transferable) of Gene_expression (transferable) of IL-23 associated with inflammation and rheumatoid arthritis
18) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.51 Pain Relevance 0.69
S and AR-C67085, two effective agonists of the P2Y11 receptor, cause inhibition of IL-12 output without enhancing IL-23 expression [65].
Neg (without) Positive_regulation (enhancing) of Gene_expression (expression) of IL-23 associated with agonist
19) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.12
Meanwhile, IL10-mediated sustained Stat3 activation in TAMs represses IL12 expression and promotes production of IL23 (comprising IL23a/IL12b heterodimers), which helps to propagate the Th17 T-cell subset [129].
Positive_regulation (promotes) of Gene_expression (production) of IL23 in Th17 T-cell
20) Confidence 0.05 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.99 Pain Relevance 0.20

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