INT204795

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 15.32
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Anatomy Link Frequency
photoreceptors 4
retinas 1
osteoblasts 1
Xiap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 215 99.64 Very High Very High Very High
ischemia 8 89.56 High High
withdrawal 35 22.32 Low Low
cINOD 10 12.68 Low Low
anesthesia 16 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
Immobilon 8 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1238 100.00 Very High Very High Very High
Retina Disease 200 97.44 Very High Very High Very High
Ocular Hypertension 8 96.28 Very High Very High Very High
Retinal Degeneration 96 96.20 Very High Very High Very High
Death 177 92.96 High High
Ganglion Cysts 8 92.52 High High
Disease 80 91.24 High High
Parkinson's Disease 8 90.08 High High
Cv Unclassified Under Development 8 89.56 High High
Stress 37 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, immunohistochemistry confirmed XIAP overexpression at sites of photoreceptor preservation (Fig 3B).
Gene_expression (overexpression) of XIAP in photoreceptor associated with apoptosis
1) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 0.77 Pain Relevance 0
Western blotting confirmed that the HA-tagged XIAP protein was overexpressed in the retinas of injected eyes and undetectable in the contralateral control eyes (Fig. 3A).
Gene_expression (overexpressed) of XIAP protein in retinas associated with apoptosis
2) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 0.83 Pain Relevance 0
We show strong preservation of ONL morphology coincident with XIAP over-expression in both P23H and S334ter rats, while non-injected controls and AAV-GFP-treated animals undergo progressive degeneration.
Gene_expression (over) of XIAP associated with apoptosis
3) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 1.45 Pain Relevance 0
We show strong preservation of ONL morphology coincident with XIAP over-expression in both P23H and S334ter rats, while non-injected controls and AAV-GFP-treated animals undergo progressive degeneration.
Gene_expression (expression) of XIAP associated with apoptosis
4) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 1.45 Pain Relevance 0
In addition, we have previously shown that XIAP over-expression can protect photoreceptors both structurally and functionally in a chemotoxic animal model of retinal degeneration [32], [33].
Gene_expression (over) of XIAP in photoreceptors associated with retinal degeneration and apoptosis
5) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 2.54 Pain Relevance 0.04
We show strong preservation of ONL morphology coincident with XIAP over-expression in both P23H and S334ter rats, while non-injected controls and AAV-GFP-treated animals undergo progressive degeneration.
Gene_expression (-) of XIAP associated with apoptosis
6) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 1.45 Pain Relevance 0
In addition, we have previously shown that XIAP over-expression can protect photoreceptors both structurally and functionally in a chemotoxic animal model of retinal degeneration [32], [33].
Gene_expression (expression) of XIAP in photoreceptors associated with retinal degeneration and apoptosis
7) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 2.55 Pain Relevance 0.04
In addition, we have previously shown that XIAP over-expression can protect photoreceptors both structurally and functionally in a chemotoxic animal model of retinal degeneration [32], [33].
Gene_expression (-) of XIAP in photoreceptors associated with retinal degeneration and apoptosis
8) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 2.54 Pain Relevance 0.04
In order to explore the possible downstream effectors of GC-induced apoptosis further, we employed rtqPCR to examine the expression of the major families of prosurvival genes (Bcl-2, Bcl-XL, IAP-1, IAP-2, XIAP, FLIPLong and FLIPShort) in osteoblasts subjected to high-dose Dex.
Spec (examine) Gene_expression (expression) of XIAP in osteoblasts associated with apoptosis and dexamethasone
9) Confidence 0.49 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.55 Pain Relevance 0.23
Instead, Dex up-regulated the expression of Bcl-XL, IAP-2 and XIAP, while the transcript levels of the anti-apoptotic proteins Bcl-2, IAP-1, FLIPLong and FLIPShort were unaltered by Dex treatment.
Gene_expression (expression) of XIAP associated with apoptosis and dexamethasone
10) Confidence 0.49 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.55 Pain Relevance 0.27
Briefly, gene transcript levels of the GC-insensitive house keeping gene, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the anti-apoptotic mouse genes Bcl-2, Bcl-XL, IAP-1, IAP-2, X-linked IAP (XIAP), FLIPLong and FLIPShort were quantified by rtqPCR on a LightCycler (Roche Diagnostic Systems).
Gene_expression (quantified) of XIAP associated with apoptosis
11) Confidence 0.43 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.29 Pain Relevance 0.03
 ; mouse XIAP (accession no.
Gene_expression (accession) of XIAP
12) Confidence 0.37 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.06 Pain Relevance 0
Briefly, gene transcript levels of the GC-insensitive house keeping gene, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the anti-apoptotic mouse genes Bcl-2, Bcl-XL, IAP-1, IAP-2, X-linked IAP (XIAP), FLIPLong and FLIPShort were quantified by rtqPCR on a LightCycler (Roche Diagnostic Systems).
Gene_expression (quantified) of X-linked IAP associated with apoptosis
13) Confidence 0.37 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.29 Pain Relevance 0.03

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