INT204805

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.98
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Xiap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 43 99.84 Very High Very High Very High
withdrawal 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 368 100.00 Very High Very High Very High
Death 55 99.16 Very High Very High Very High
Retina Disease 75 98.84 Very High Very High Very High
Retinal Diseases 9 96.84 Very High Very High Very High
Retinal Degeneration 36 92.76 High High
Disease 30 92.76 High High
Targeted Disruption 28 87.36 High High
Osteoporosis 27 86.80 High High
Hepatitis 3 19.92 Low Low
Phototoxic Dermatitis 3 14.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electroretinography was conducted to assess the effects of XIAP gene therapy on retinal function.
Regulation (effects) of XIAP gene associated with apoptosis
1) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 0.35 Pain Relevance 0
Since P23H also represents the larger group of class II rhodopsin mutations, XIAP gene therapy may be equally effective in protecting against other RP-causing misfolding rhodopsin mutations.
Spec (may) Regulation (effective) of XIAP gene associated with apoptosis and retina disease
2) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 0.78 Pain Relevance 0
Although these anti-apoptotic genes responded to different mitogenic conditions, Dex failed to repress their expression, and in fact significantly up-regulated Bcl-XL, IAP-2 and XIAP.
Regulation (regulated) of XIAP associated with apoptosis and dexamethasone
3) Confidence 0.29 Published 2007 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2173947 Disease Relevance 1.15 Pain Relevance 0.17
Thus, targeting apoptosis through XIAP gene therapy may yield a general and widely applicable approach for these types of retinal disease.


Regulation (targeting) of XIAP gene associated with apoptosis and retinal diseases
4) Confidence 0.24 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 1.70 Pain Relevance 0

General Comments

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