INT204838

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 1.61
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
microglia 4
midbrain 2
neuron 1
neuropil 1
white matter 1
Iba1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 15 98.18 Very High Very High Very High
midbrain 61 98.06 Very High Very High Very High
dorsal root ganglion 32 90.00 High High
imagery 64 86.96 High High
Spinal cord 61 86.32 High High
Nerve growth factor 96 78.48 Quite High
Substantia nigra 120 77.20 Quite High
Demyelination 6 45.04 Quite Low
Spinal nerve ligature 2 27.44 Quite Low
Dopamine 48 22.40 Low Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 4 99.72 Very High Very High Very High
Brain Injury 100 98.76 Very High Very High Very High
Injury 129 94.24 High High
Blister 2 90.96 High High
Ganglion Cysts 32 90.00 High High
Targeted Disruption 118 79.80 Quite High
Diffuse Axonal Injury 16 70.24 Quite High
Disease 78 50.00 Quite Low
Nervous System Injury 18 50.00 Quite Low
Death 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
500 µm2 of neuropil in each) than areas not associated with IBA1-positive processes (382±18 nm2; p<0.0002; Figure 1E).
IBA1 Binding (associated) of in neuropil
1) Confidence 0.29 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0 Pain Relevance 0
In addition to their IBA1 immunoreactivity, microglial cell bodies were recognized by their small size and the clumps of chromatin beneath their nuclear envelope and throughout their nucleoplasm.
IBA1 Binding (recognized) of in microglial cell
2) Confidence 0.25 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0 Pain Relevance 0.08
Anti-CD31 was used to stain the endothelial cells of the vasculature, whereas anti-ionized calcium binding adapter molecule 1 (IBA1), anti-glial fibrillary acidic protein (GFAP) and anti-neuron specific nuclear protein (NEUN) labeled cells of myeloid (macrophages and microglia), astroglial and neuronal lineages, respectively.
IBA1 Binding (binding) of in neuron
3) Confidence 0.24 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0 Pain Relevance 0
Louis, MO), ionized calcium binding adaptor molecule-1 (Iba1, 1:1000, Wako Chemicals USA, Richmond, VA), tyrosine hydroxylase (TH, 1:1000, Pel-Freez Biologicals, Rogers, AR), ?
Iba1 Binding (binding) of
4) Confidence 0.23 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.04
(rabbit, 1:50; Santa Cruz Biotechnology; mouse, 1:50; BD Transduction Laboratories), CGRP (rabbit, 1:1000; Sigma), NeuN (mouse, 1:100; Chemicon), GFAP (mouse, 1:400; Chemicon) and Iba 1 (rabbit, 1:500, Wako Pure Chemical Industries, Ltd., Osaka, Japan).
Iba 1 Binding (rabbit) of associated with calcitonin gene-related peptide
5) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.09 Pain Relevance 0.09
IBA-1-ir microglia in these studies colocalize IGF, which supports a neuroprotective and supportive role for microglia in the generation of neuroblasts within the SVZ [18].
IBA-1-ir Binding (microglia) of in microglia
6) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.60 Pain Relevance 0.17
Increase in IBA-1 immunoreactive microglia within the white matter after TBI
IBA-1 Binding (microglia) of in white matter associated with brain injury
7) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.92 Pain Relevance 0
For visualization of microglia, midbrain sections were immunostained with an antibody recognizing the microglial marker ionizing calcium-binding adaptor molecule 1 (Iba-1) (1?
Iba-1 Binding (binding) of in midbrain associated with midbrain
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920329 Disease Relevance 0 Pain Relevance 0.15
For visualization of microglia, midbrain sections were immunostained with an antibody recognizing the microglial marker ionizing calcium-binding adaptor molecule 1 (Iba-1) (1?
Iba-1 Binding (binding) of in midbrain associated with midbrain
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920329 Disease Relevance 0 Pain Relevance 0.15
For visualization of microglia, midbrain sections were immunostained with an antibody recognizing the microglial marker ionizing calcium-binding adaptor molecule 1 (Iba-1) (1?
Iba-1 Binding (binding) of in microglia associated with midbrain
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920329 Disease Relevance 0 Pain Relevance 0.15
For visualization of microglia, midbrain sections were immunostained with an antibody recognizing the microglial marker ionizing calcium-binding adaptor molecule 1 (Iba-1) (1?
Iba-1 Binding (binding) of in microglia associated with midbrain
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920329 Disease Relevance 0 Pain Relevance 0.15

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