INT204842

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.60
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) Golgi apparatus (Cd44) plasma membrane (Cd44)
nucleus (Cd44) protein complex (Cd44) cytoplasm (Cd44)
Anatomy Link Frequency
T cells 3
macrophage 1
capillary 1
Cd44 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 26 95.68 Very High Very High Very High
chemokine 35 95.56 Very High Very High Very High
imagery 13 95.20 Very High Very High Very High
Inflammation 116 93.76 High High
cva 2 92.74 High High
Central nervous system 70 84.76 Quite High
Inflammatory response 16 83.48 Quite High
cytokine 62 82.00 Quite High
rheumatoid arthritis 1 64.56 Quite High
cINOD 1 64.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 150 98.94 Very High Very High Very High
Disease 31 98.60 Very High Very High Very High
Adhesions 45 98.28 Very High Very High Very High
Cervical Cancer 3 98.00 Very High Very High Very High
Injury 166 97.92 Very High Very High Very High
Increased Venous Pressure Under Development 3 96.30 Very High Very High Very High
Lymphopenia 5 95.80 Very High Very High Very High
Cv Unclassified Under Development 26 95.68 Very High Very High Very High
Repression 4 94.08 High High
INFLAMMATION 137 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1, ALCAM) and stabilizes CD44 mRNA, thereby promoting invadopodia formation in cervical cancer cells.
Positive_regulation (stabilizes) of CD44 associated with cervical cancer
1) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 1.16 Pain Relevance 0
The mean levels of mRNA for CD44, VCAM-1, MCP-1, and Cox-2, in fact, were elevated in 6-weeks old apoE?
Positive_regulation (elevated) of CD44
2) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.51 Pain Relevance 0.04
In all panels, the CD8+ T cell population was gated and analyzed for CD44+ (activation) and Db: VP2121–130 or Db:E7 tetramer.


Positive_regulation (activation) of CD44 in T cell
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.16 Pain Relevance 0.09
Despite severe decreases in splenic T cell numbers, there was no upregulation of CD44 or downregulation of CD62L in spleen (Figure 3C), changes that characterize T cells that have undergone lymphopenia-induced homeostatic proliferation.
Neg (no) Positive_regulation (upregulation) of CD44 in T cells associated with lymphopenia
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.32 Pain Relevance 0.08
In this particular case, RU486 essentially prevented gene upregulation (Cd44, Stat1, Ch25h and Il1b) or downregulation (C1qa and Hexb) by LPS.
Positive_regulation (upregulation) of Cd44
5) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.09 Pain Relevance 0.09
Also, a recent study demonstrated that rapid CD44 upregulation on renal capillary endothelial cells mediates neutrophil recruitment to the postischemic tissue in a renal ischemia-perfusion mouse model.
Positive_regulation (upregulation) of CD44 in capillary associated with ischemia
6) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.03 Pain Relevance 0.11
Expanding T cells down-regulated CD62L and up-regulated CD44 in Tx-pLN and Tx-mLN to a similar extent, which is indicative of their effector status (Fig.
Positive_regulation (up-regulated) of CD44 in T cells
7) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571923 Disease Relevance 0 Pain Relevance 0
Noted differences of the cytospin preparations relative to the heterotransplanted tumors were a decrease in keratin and EFGr staining and an increase in E-cadherin and CD44 positivity.
Positive_regulation (increase) of CD44 associated with cancer
8) Confidence 0.28 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.27 Pain Relevance 0
The higher levels of MIF associated with this particular variant also correlated with progressive disease.16 In relation to malignant diseases, individuals carrying the seven-repeat allele were also found to have an increased incidence of prostate cancer.17 MIF biological activity has also been implicated in the pathogenesis of atherosclerosis and abdominal aortic aneurysm.18 In the context of atherosclerosis, MIF has also been identified as a non-cognate receptor of CXCR2 and CXCR4 and has functional chemokine activity in evolving atherosclerosis mediating monocyte arrest and the formation of plaques.19 Additionally, as part of this disease process MIF can induce the CXCR ligand, Interleukin (IL)-8 and regulators of macrophage infiltration ICAM-1 and CD44, confirming its relevance in this disease.20
Positive_regulation (infiltration) of CD44 in macrophage associated with chemokine, malignant neoplastic disease, cva, increased venous pressure under development, disease and reprotox - general 1
9) Confidence 0.11 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 2.05 Pain Relevance 0.35

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