INT204852

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.15
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 1
macrophage 1
dendritic cells 1
astrocytes 1
Cd83 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 17 100.00 Very High Very High Very High
Inflammation 126 98.40 Very High Very High Very High
Neuropeptide 32 83.68 Quite High
Central nervous system 45 76.20 Quite High
cytokine 19 69.92 Quite High
dexamethasone 12 50.72 Quite High
Somatostatin 17 44.68 Quite Low
member 8 1 41.16 Quite Low
Glutamate 2 38.88 Quite Low
substance P 42 31.68 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 136 98.40 Very High Very High Very High
Cancer 2 97.84 Very High Very High Very High
Severe Combined Immunodeficiency 1 97.60 Very High Very High Very High
Necrosis 2 97.56 Very High Very High Very High
Diabetes Mellitus 156 95.76 Very High Very High Very High
Increased Venous Pressure Under Development 77 95.70 Very High Very High Very High
Acute-phase Reaction 3 92.32 High High
Repression 12 89.92 High High
Hyperplasia 1 82.80 Quite High
Death 25 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry was combined with the in situ hybridization histochemistry protocol to determine the types of cells that express Cd44, Cd83, Cp, Lcn2, Saa3, Stat1 and Tnfsf9 transcripts.
Gene_expression (express) of Cd83
1) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0 Pain Relevance 0
According to our double labeling procedure, Cd44, Tnfsf9 and Cd83 are expressed mainly by microglial cells, Lcn2 by endothelial cells and Saa3 transcript by microglia and few astrocytes.
Gene_expression (expressed) of Cd83 in astrocytes
2) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.15 Pain Relevance 0
The lack of this gene subset in association with the exacerbated expression of genes identified here as GR repressed (chemokines, Tnfsf9, Cd83, etc.) can clearly result in increased inflammation at latter time-points and in the emergence of a detrimental microglial/macrophage phenotype.
Gene_expression (expression) of Cd83 in macrophage associated with chemokine and inflammation
3) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.84 Pain Relevance 0.40
Cells were washed again, and the expression of MHC II, CD83 and CD86 was quantified using flow cytometry (FACS Canto II, Becton Dickinson).
Gene_expression (expression) of CD83 in CD86
4) Confidence 0.37 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003783 Disease Relevance 0 Pain Relevance 0
The comparison of mature DCs between patients and controls indicated a difference in CD83 expression.
Gene_expression (expression) of CD83
5) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.72 Pain Relevance 0
In the experimental mouse model of GCA, systemic administration of ligands for Toll-like receptor (TLR)2 or TLR4 in human artery-SCID chimeras led to differentiation of adventitial dendritic cells into chemokine-producing effector cells with high-level expression of both CD83 and CD86 and mediated T-cell recruitment through release of interleukin (IL)-18 [4].
Gene_expression (expression) of CD83 in dendritic cells associated with chemokine, severe combined immunodeficiency and increased venous pressure under development
6) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 1.04 Pain Relevance 0.16
By signalling through the VPAC1 receptor, VIP was shown to induce the maturation of immature DCs leading to an enhanced production of IL-12 and an enhanced expression of the DC-maturation marker CD83, especially in the presence of suboptimal amounts of tumour necrosis factor-?
Gene_expression (expression) of CD83 associated with necrosis and cancer
7) Confidence 0.24 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.40 Pain Relevance 0.20

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