INT204853

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.29
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 2
dendritic cell 1
Cd83 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 97.08 Very High Very High Very High
chemokine 6 96.86 Very High Very High Very High
Central nervous system 30 90.36 High High
Inflammation 70 21.96 Low Low
ketamine 8 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
transdermal 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 8 99.84 Very High Very High Very High
Immunization 96 51.60 Quite High
Diphtheria 16 50.00 Quite Low
Death 14 50.00 Quite Low
INFLAMMATION 78 21.96 Low Low
Infection 22 5.00 Very Low Very Low Very Low
Demyelinating Disease 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Meningitis 10 5.00 Very Low Very Low Very Low
Vibrio Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These included acute-phase reactants (APRs) (Saa3, Lcn2 and Serpina3n), genes with GR-mediated repression on LPS induction (Gem, Cd83 and Tnfsf9) and other transcripts modulated by GR signaling.
Positive_regulation (induction) of Cd83 associated with repression
1) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.10 Pain Relevance 0.10
These genes can be divided into: a) those already upregulated by LPS, such as chemokines, cytokines, JAK-STAT pathway, regulators of transcription and others; b) genes only induced when LPS is combined to RU486, namely a cell-surface antigen of activated dendritic cell (Cd83), a GTPase of the RGK family (Gem) and a transcription factor of the CNC-bZip family (Bach1).
Positive_regulation (activated) of Cd83 in dendritic cell associated with chemokine and cytokine
2) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.09 Pain Relevance 0.10
Fig. 6Stimulatory effects of DT formulations on immature DCs as indicated by the up-regulation of the surface markers MHC II, CD83 and CD86.
Positive_regulation (he up-regulat) of CD83 in CD86
3) Confidence 0.22 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003783 Disease Relevance 0 Pain Relevance 0
The up-regulation of the surface markers, MHC II, CD83 and CD86, was determined after culturing immature DCs in the presence of the DT formulations (Fig. 6).
Positive_regulation (he up-regulat) of CD83 in CD86
4) Confidence 0.10 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003783 Disease Relevance 0.10 Pain Relevance 0

General Comments

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