INT204863

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.57
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hexb) carbohydrate metabolic process (Hexb) lysosome (Hexb)
Anatomy Link Frequency
macrophages 1
neutrophils 1
Hexb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 30 96.08 Very High Very High Very High
Chronic pancreatitis 4 89.24 High High
Inflammation 80 66.96 Quite High
Central nervous system 30 29.60 Quite Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 110 95.72 Very High Very High Very High
Death 118 91.48 High High
Pancreatitis 44 89.24 High High
Repression 12 89.12 High High
Stress 74 50.96 Quite High
Neurodegenerative Disease 6 22.08 Low Low
Apoptosis 56 5.00 Very Low Very Low Very Low
Frailty 44 5.00 Very Low Very Low Very Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Infection 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutant samples showed a significant increase in genes predominately expressed in infiltrating macrophages and neutrophils such as Mac-2 (a macrophage marker), Mmp12 (macrophage elastase), lysosomal proteins (Lip1 and Hexb), and Lcn2 (neutrophil gelatinase-associated lipocalin precursor) (see Additional file 1; also see Figure 2A for Mac-2).
Gene_expression (expressed) of Hexb in macrophages
1) Confidence 0.44 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.20 Pain Relevance 0.26
The expression pattern of C1qa and Hexb is highly suggestive of ubiquitous constitutive expression, which was selectively repressed by the endotoxin in the ipsilateral side of injection (Fig. 4B).
Gene_expression (expression) of Hexb
2) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.08 Pain Relevance 0
The expression pattern of C1qa and Hexb is highly suggestive of ubiquitous constitutive expression, which was selectively repressed by the endotoxin in the ipsilateral side of injection (Fig. 4B).
Gene_expression (expression) of Hexb
3) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.09 Pain Relevance 0
Mutant samples showed a significant increase in genes predominately expressed in infiltrating macrophages and neutrophils such as Mac-2 (a macrophage marker), Mmp12 (macrophage elastase), lysosomal proteins (Lip1 and Hexb), and Lcn2 (neutrophil gelatinase-associated lipocalin precursor) (see Additional file 1; also see Figure 2A for Mac-2).
Gene_expression (expressed) of Hexb in neutrophils
4) Confidence 0.15 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.20 Pain Relevance 0.26

General Comments

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