INT204864

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.05
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
brain 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 106 92.20 High High
chemokine 4 89.56 High High
Central nervous system 16 84.48 Quite High
ischemia 4 68.04 Quite High
dexamethasone 4 37.76 Quite Low
Inflammatory response 11 23.08 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
Hippocampus 13 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhagic Shock 32 98.24 Very High Very High Very High
INFLAMMATION 115 92.20 High High
Cognitive Disorder 18 90.92 High High
Adult Respiratory Distress Syndrome 27 90.68 High High
Shock 8 90.36 High High
Repression 4 85.92 High High
Injury 19 85.12 High High
Acute-phase Reaction 1 79.36 Quite High
Cv Unclassified Under Development 4 68.04 Quite High
Infection 14 50.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting to note that many regulated genes that exhibited a particular profile (i.e., RU486 prevented their downregulation to LPS) are related to brain development and not necessarily to myeloid functions.
Negative_regulation (prevented) of Negative_regulation (downregulation) of LPS in brain
1) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.79 Pain Relevance 0.41
, whereas antecedent HS prevents the decrease in TLR4 gene transcription in response to LPS; also, LPS-induced TLR4 mRNA destabilization is reduced in the AM?
Negative_regulation (reduced) of Negative_regulation (destabilization) of TLR4 mRNA associated with hemorrhagic shock
2) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 1.17 Pain Relevance 0.15
However, in the testing trial (day 1), the mice which received a single intraperitoneal injection of LPS (250 ?
Negative_regulation (received) of Negative_regulation (injection) of LPS
3) Confidence 0.17 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2556656 Disease Relevance 0.09 Pain Relevance 0

General Comments

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