INT204895

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cp) intracellular (Tlr4) cytoplasm (Tlr4)
signal transduction (Tlr4) extracellular space (Cp) extracellular region (Cp)
Tlr4 (Mus musculus)
Cp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 68 92.80 High High
Central nervous system 30 24.80 Low Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 74 92.80 High High
Neurodegenerative Disease 6 87.68 High High
Death 14 50.00 Quite Low
Repression 8 41.00 Quite Low
Infection 22 5.00 Very Low Very Low Very Low
Demyelinating Disease 12 5.00 Very Low Very Low Very Low
Meningitis 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Bacterial Meningitis 4 5.00 Very Low Very Low Very Low
Pneumococcal Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, figure 6D shows that the four different probe sets used in the gene chip generated the same data, which all together provide very solid evidence that GR blockage is able to prevent LPS-induced Cp gene expression.
LPS Positive_regulation (induced) of Gene_expression (expression) of Cp gene
1) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.21 Pain Relevance 0.04
Quantification of in situ hybridization data indicated that RU486 significantly prevented LPS-induced Cp gene expression, but only at the higher dose tested (Fig. 5A, B).
LPS Positive_regulation (induced) of Gene_expression (expression) of Cp gene
2) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.26 Pain Relevance 0.05

General Comments

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