INT20492

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Context Info
Confidence 0.76
First Reported 1987
Last Reported 2011
Negated 2
Speculated 6
Reported most in Body
Documents 89
Total Number 95
Disease Relevance 81.36
Pain Relevance 46.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP12) extracellular region (MMP12) proteinaceous extracellular matrix (MMP12)
Anatomy Link Frequency
macrophages 13
smooth muscle cells 9
alveolar macrophages 3
neutrophils 2
mammary glands 1
MMP12 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 8488 100.00 Very High Very High Very High
Enkephalin 91 100.00 Very High Very High Very High
Inflammation 1925 99.90 Very High Very High Very High
cytokine 960 99.88 Very High Very High Very High
chemokine 14 99.44 Very High Very High Very High
dexamethasone 301 99.04 Very High Very High Very High
Inflammatory mediators 90 97.46 Very High Very High Very High
Pain 17 97.16 Very High Very High Very High
corticosteroid 344 96.92 Very High Very High Very High
Neuropeptide 4 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ehrlichiosis 39 100.00 Very High Very High Very High
Infection 34 100.00 Very High Very High Very High
Multiple Hereditary Exostoses 7 100.00 Very High Very High Very High
INFLAMMATION 2190 99.90 Very High Very High Very High
Nicotine Addiction 4762 99.84 Very High Very High Very High
Colon Cancer 4 99.84 Very High Very High Very High
Pulmonary Disease 3651 99.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 31 99.68 Very High Very High Very High
Cancer 372 99.64 Very High Very High Very High
Disease 233 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that these three genotypes may result in different phenotypic expression of HME and thus explain the variable manifestations of the disease.
Gene_expression (expression) of HME associated with disease and multiple hereditary exostoses
1) Confidence 0.76 Published 1999 Journal J Pediatr Orthop Section Abstract Doc Link 10573350 Disease Relevance 0.79 Pain Relevance 0.08
Also, an increased number of BAL MMP-12+-macrophages in COPD ex-smokers, compared to 'healthy' smoking subjects, let us hypothesize that MMP-12 expression is induced not only by cigarette smoking, but may be an obligatory to the development of COPD.
Gene_expression (expression) of MMP-12 in macrophages associated with nicotine addiction, pulmonary disease and metalloproteinase
2) Confidence 0.75 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.58 Pain Relevance 0.58
Overproduction of MMP-12 causes pathological ECM protein breakdown and excessive airway remodeling, which has been implicated in a range of respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD).
Gene_expression (Overproduction) of MMP-12 in respiratory associated with asthma, pulmonary disease, metalloproteinase, respiratory disease and airway remodeling
3) Confidence 0.75 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.32 Pain Relevance 0.90
MMP-12, also called macrophage metalloelastase, was originally detected in alveolar macrophages of cigarette smokers [7].
Gene_expression (detected) of MMP-12 in alveolar macrophages associated with nicotine addiction and metalloproteinase
4) Confidence 0.75 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.36 Pain Relevance 0.58
This characteristic stroma may indicate secretion of specific cytokines, and we, in this study, first demonstrated marked expression of VEGF and MMP12.
Gene_expression (expression) of MMP12 in stroma associated with cytokine
5) Confidence 0.69 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.74 Pain Relevance 0.15
Immunohistochemically, in both cases, tumoural and non-tumoural cells strongly expressed VEGF and MMP12, which promote macrophage migration and angiogenesis.
Gene_expression (expressed) of MMP12 in macrophage
6) Confidence 0.69 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2936386 Disease Relevance 0.79 Pain Relevance 0.07
Prominent expression of VEGF and MMP12 was observed in most tumor cells, most inflammatory cells, and even neighboring normal mammary glands both in Case 1 and Case 2 (Figure 2G-R).
Gene_expression (expression) of MMP12 in mammary glands associated with inflammation and cancer
7) Confidence 0.69 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.40 Pain Relevance 0.05
Despite different tumoural histology, two cases displayed common microenvironments with expression of VEGF and MMP12, suggesting enhanced macrophage migration and angiogenesis.
Gene_expression (expression) of MMP12 in macrophage
8) Confidence 0.69 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.71 Pain Relevance 0.13
The OGCs, in both cases, also displayed marked expression of VEGF and MMP12.


Gene_expression (expression) of MMP12
9) Confidence 0.69 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.34 Pain Relevance 0.05
To assess the microenvironment of the tumors, we examined the expression of two chemoattractants for macrophage migration and angiogenesis, VEGF and MMP12.
Spec (examined) Gene_expression (expression) of MMP12 in macrophage associated with cancer
10) Confidence 0.69 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.35 Pain Relevance 0.05
The research described in this article defined the existence of one enkephalin, methionine enkephalin (ME), in an extract of human tooth pulp tissue and the effect of orthodontic force on that ME concentration.
Gene_expression (existence) of ME in tooth pulp associated with enkephalin
11) Confidence 0.67 Published 1987 Journal Am J Orthod Dentofacial Orthop Section Abstract Doc Link 3474889 Disease Relevance 0.45 Pain Relevance 0.88
Also, Molet et al., have reported an increase of MMP-12 in BAL and bronchial biopsies of COPD patients compared to controls [30], while they have not investigated an expression of MMP-12 according to smoking status.
Spec (investigated) Gene_expression (expression) of MMP-12 associated with nicotine addiction, pulmonary disease and metalloproteinase
12) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.68 Pain Relevance 0.61
Absence of significant differences in MMP-12 expression in IS may be explained by predominance of neutrophils, in COPD smokers and ex-smokers, which obviously do not express MMP-12.
Gene_expression (expression) of MMP-12 in neutrophils associated with nicotine addiction, pulmonary disease and metalloproteinase
13) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.23 Pain Relevance 0.60
We analysed an expression of MMP-12 active form using immunocytochemistry.
Spec (analysed) Gene_expression (expression) of MMP-12 associated with metalloproteinase
14) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.15 Pain Relevance 0.58
Also, according to a previous study, showing an increase in MMP-12 in the induced sputum (IS) of COPD patients [20], we have assessed an expression of MMP-12 in IS and BAL cells from these COPD and healthy subjects groups.
Gene_expression (expression) of MMP-12 in sputum associated with pulmonary disease and metalloproteinase
15) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 1.89 Pain Relevance 0.55
Expression of MMP-12 in IS and BAL cells
Gene_expression (Expression) of MMP-12 associated with metalloproteinase
16) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 3.22 Pain Relevance 0.24
Absence of significant differences in MMP-12 expression in IS may be explained by predominance of neutrophils, in COPD smokers and ex-smokers, which obviously do not express MMP-12.
Neg (not) Gene_expression (express) of MMP-12 in neutrophils associated with nicotine addiction, pulmonary disease and metalloproteinase
17) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.16 Pain Relevance 0.59
It is important to note, that we used DTT for preparation of IS samples, which may interfere with expression of MMP-12.
Gene_expression (expression) of MMP-12 associated with metalloproteinase
18) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 0.18 Pain Relevance 0.42
'Healthy' smokers had higher number of BAL MMP-12+-macrophages, than never-smokers supporting the fact of smoking impact in MMP-12 expression.
Gene_expression (expression) of MMP-12 in macrophages associated with nicotine addiction and metalloproteinase
19) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.65 Pain Relevance 0.56
MMP-12 expression in IS and BAL cytospin preparations was detected immunocytochemically.
Gene_expression (expression) of MMP-12 associated with metalloproteinase
20) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 0 Pain Relevance 0.27

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