INT204929
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
DVS sustained release was considered safe in healthy volunteers up to a single dose of 750 mg27 and was well tolerated in multiple doses up to 450 mg.28 The plasma protein binding of DVS is low (30%) and is independent of drug concentration. | |||||||||||||||
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Data pooled from 7 clinical trials, showed that treatment with DVS was associated with small mean decreases in weight in the short term (1 kg), which persisted up to 6 months with a small mean increase (<1 kg) and was comparable to placebo.46 | |||||||||||||||
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The change on HAM-D17 total score from baseline was greater for DVS than for placebo, with a magnitude of effect = ? | |||||||||||||||
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Four deaths (two HFMD and two non-HFMD cases) were associated with HEV71. | |||||||||||||||
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These mutants were found to lack the ability to interact with HEV-neutralizing monoclonal antibody, mAb 8C11 (Figure 5). | |||||||||||||||
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Taken together the presence of neutralizing antibody binding sites of HEV on E2s, and the shape of the dimer, we suggest that E2s is present on the surface protrusions of HEV shown in the electron microscopic structure [5]. | |||||||||||||||
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To verify that the dimerization of E2s is crucial for the host interaction of HEV, several mutations on dimer interface regions of E2/E2s were carried out (Figures 5 and 6), and their roles in destabilizing the dimer formation were studied. | |||||||||||||||
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HEV antibody recognition and E2s | |||||||||||||||
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Moreover, two of 13 linear epitope-reactive antibodies and 15 of 20 conformational determinant -reactive antibodies can bind genotype I and/or genotype IV HEV. | |||||||||||||||
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Monoclonal antibodies reactive against the abovementioned regions bind to live HEV, and at least two monoclonal antibodies (8C11 and 8H3) could neutralize the infectivity of HEV [8]. | |||||||||||||||
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Neutralizing antibodies such as 8C11 and 8H3 bind with native HEV [8], as well as with the dimeric form of E2 constructs [6],[19]. | |||||||||||||||
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This article reports the crystal structure of the HEV capsid protein domain E2s (protruding domain), along with functional studies, which illustrate the tight homodimeric state of E2s and that dimerization is essential for both HEVhost interactions and disease progression. | |||||||||||||||
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Together, gender, HEV, and gender × HEV interaction were able to account for about 60% of the individual variation in measures of gray matter volume. | |||||||||||||||
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Together, gender, HEV, and gender × HEV interaction were able to account for about 60% of the individual variation in measures of gray matter volume. | |||||||||||||||
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Overall, the interaction between gender and HEV had an eta-squared of 0.39 on total GMV. | |||||||||||||||
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There was a strong interaction between HEV-laterality and gender, which together accounted for 60% of individual variability in total grey matter volume (GMV). | |||||||||||||||
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However, there were even more marked interactions between HEV and gender. | |||||||||||||||
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In contrast, direction of HEV, gender, and their interaction accounted for up to 60% of the variance. | |||||||||||||||
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General Comments
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